Synthesis of tripeptide mimetics based on dihydroquinolinone and benzoxazinone scaffolds

Dantas de Araujo, Aline, Christensen, Caspar, Buchardt, Jens, Kent, Stephen B. H. and Alewood, Paul F. (2011) Synthesis of tripeptide mimetics based on dihydroquinolinone and benzoxazinone scaffolds. Chemistry: A European Journal, 17 50: 13983-13986. doi:10.1002/chem.201102732


Author Dantas de Araujo, Aline
Christensen, Caspar
Buchardt, Jens
Kent, Stephen B. H.
Alewood, Paul F.
Title Synthesis of tripeptide mimetics based on dihydroquinolinone and benzoxazinone scaffolds
Journal name Chemistry: A European Journal   Check publisher's open access policy
ISSN 0947-6539
1521-3765
Publication date 2011-12
Sub-type Article (original research)
DOI 10.1002/chem.201102732
Volume 17
Issue 50
Start page 13983
End page 13986
Total pages 4
Place of publication Weinheim, Germany
Publisher Wiley
Collection year 2012
Language eng
Abstract In the image: The design and synthesis of peptidomimetics that maintain the configuration of the triad Asp-Thr-Gly found in the catalytic site of the HIV-1 protease (see scheme) are described. By using regioselective nitration and reductive lactamisation, the bicyclic mimetics were constructed in a simple fashion and further equipped with appropriate protecting groups suitable for application in solid-phase peptide synthesis.
Keyword Benzoxazinones
Dihydroquinolinones
Heterocycles
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 2 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 12 Feb 2012, 00:21:14 EST by System User on behalf of Institute for Molecular Bioscience