Delivery of maternal thyroid hormones to the fetus

Patel, Jatin, Landers, Kelly, Li, Huika, Mortimer, Robin H. and Richard, Kerry (2011) Delivery of maternal thyroid hormones to the fetus. Trends in Endocrinology and Metabolism, 22 5: 164-170. doi:10.1016/j.tem.2011.02.002


Author Patel, Jatin
Landers, Kelly
Li, Huika
Mortimer, Robin H.
Richard, Kerry
Title Delivery of maternal thyroid hormones to the fetus
Journal name Trends in Endocrinology and Metabolism   Check publisher's open access policy
ISSN 1043-2760
1879-3061
Publication date 2011-05
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.tem.2011.02.002
Volume 22
Issue 5
Start page 164
End page 170
Total pages 7
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2012
Language eng
Formatted abstract
Thyroid hormones (THs) play an essential role in ensuring normal fetal development, particularly that of the central nervous system. Before 16 weeks gestation, the fetus relies solely on transplacental delivery of maternal T4, and clinical studies suggest that even mild maternal thyroid hormone deficiency adversely affects the intellectual function of offspring. Maternofetal TH transfer is regulated by trophoblast cell membrane transporters, which mediate influx and efflux of THs, placental deiodinases D3 and D2, which control intraplacental TH levels, and TH-binding proteins (transthyretin), which provide transport roles in the placenta. This review discusses new information about mechanisms of transplacental delivery of T4 to the fetus, providing insight into complex processes that are vitally important for normal fetal development.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2012 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 30 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 43 times in Scopus Article | Citations
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Created: Fri, 10 Feb 2012, 09:32:34 EST by Roheen Gill on behalf of UQ Centre for Clinical Research