Associations of marker panel scores with feed intake and efficiency traits in beef cattle using preselected single nucleotide polymorphisms

Mujibi, F. D. N., Nkrumah, J. D., Durunna, O. N., Grant, J. R., Mah, J., Wang, Z., Basarab, J., Plastow, G., Crews, D. H. and Moore, S. S. (2011) Associations of marker panel scores with feed intake and efficiency traits in beef cattle using preselected single nucleotide polymorphisms. Journal of Animal Science, 89 11: 3362-3371. doi:10.2527/jas.2010-3362

Author Mujibi, F. D. N.
Nkrumah, J. D.
Durunna, O. N.
Grant, J. R.
Mah, J.
Wang, Z.
Basarab, J.
Plastow, G.
Crews, D. H.
Moore, S. S.
Title Associations of marker panel scores with feed intake and efficiency traits in beef cattle using preselected single nucleotide polymorphisms
Journal name Journal of Animal Science   Check publisher's open access policy
ISSN 0021-8812
Publication date 2011-11
Sub-type Article (original research)
DOI 10.2527/jas.2010-3362
Volume 89
Issue 11
Start page 3362
End page 3371
Total pages 10
Place of publication Savoy, IL, United States
Publisher American Society of Animal Science
Collection year 2012
Language eng
Formatted abstract
Because of the moderate heritability and the expense associated with collecting feed intake data, effective selection for residual feed intake would be enhanced if marker-assisted evaluation were used for accurate estimation of genetic merit. In this study, a suite of genetic markers predictive of residual feed intake, DMI, and ADG were preselected using single-marker regression analysis, and the top 100 SNP were analyzed further to provide prediction equations for the traits. The data used consisted of 728 spring-born beef steers, offspring of a cross between a composite dam line and Angus, Charolais, or University of Alberta hybrid bulls. Feed intake data were collected over a 5-yr period, with 2 groups (fall-winter and winter-spring) tested every year. Training and validation data sets were obtained by splitting the data into 2 distinct sets, by randomly splitting the data into training and testing sets based on sire family (split 1) in 5 replicates or by retaining all animals with no known pedigree relationships as the validation set (split 2). A total of 37,959 SNP were analyzed by single-marker regression, of which only the top 100 that corresponded to a P-value <0.002 were retained. The 100 SNP were then analyzed using random regression BLUP, and only SNP that were jointly significant (P < 0.05) were included in the final marker panels. The marker effects from the selected panels were used to derive the molecular breeding values, which were calculated as a weighted sum of the number of copies of the more frequent allele at each SNP locus, with the weights being the allele substitution effects. The correlation between molecular breeding value and phenotype represented the accuracy of prediction. For all traits evaluated, accuracy across breeds was low, ranging between 0.007 and 0.414. Accuracy was least in data split 2, where the validation individuals had no pedigree relationship with animals in the training data. Given the low predictive ability observed, a large number of individuals may be needed for prediction when using such an admixed population. Further, these results suggest that breed composition of the target population in which the marker panels are likely to be used should be an important consideration when developing prediction equations across breeds, especially where an admixed population is used as the training data set.
Keyword Accuracy
Molecular breeding value
Residual feed intake
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Alliance for Agriculture and Food Innovation
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Thu, 09 Feb 2012, 14:55:32 EST by Stephen Moore on behalf of Qld Alliance for Agriculture and Food Innovation