Identification of candidate markers on bovine chromosome 14 (BTA14) under milk production trait quantitative trait loci in Holstein

Marques, E., Grant, J. R., Wang, Z., Kolbehdari, D., Stothard, P., Plastow, G. and Moore, S. S. (2011) Identification of candidate markers on bovine chromosome 14 (BTA14) under milk production trait quantitative trait loci in Holstein. Journal of Animal Breeding and Genetics, 128 4: 305-313. doi:10.1111/j.1439-0388.2010.00910.x


Author Marques, E.
Grant, J. R.
Wang, Z.
Kolbehdari, D.
Stothard, P.
Plastow, G.
Moore, S. S.
Title Identification of candidate markers on bovine chromosome 14 (BTA14) under milk production trait quantitative trait loci in Holstein
Journal name Journal of Animal Breeding and Genetics   Check publisher's open access policy
ISSN 0931-2668
1439-0388
Publication date 2011-08
Sub-type Article (original research)
DOI 10.1111/j.1439-0388.2010.00910.x
Volume 128
Issue 4
Start page 305
End page 313
Total pages 9
Place of publication Berlin, Germany
Publisher Wiley-Blackwell Verlag
Collection year 2012
Language eng
Formatted abstract The objective of this study was to identify single-nucleotide polymorphisms using a bovine chromosome 14 high-density SNP panel after accounting for the effect of DGAT1. Linkage disequilibrium information and sire heterozygosity were used to select markers for linkage analysis on bovine chromosome 14 for milk production traits in 321 Holstein animals. Results show putative milk peaks at 42 and 61 cM, both at p < 0.10, a fat yield peak at 42 and 63 cM, both at p < 0.05; a protein yield peak at 42 (p < 0.01) and 84 cM (p < 0.05); fat per cent peaks at 3 (p < 0.01) and 29 cM (p < 0.05), and a protein per cent peak at 4 cM (p < 0.05). Once quantitative trait loci positions were established, allele substitution effects for all markers were evaluated using the same statistical model. Overlaying information between quantitative trait loci (QTL) and allele effect analysis enabled the identification (p < 0.01) of 20 SNPs under the milk yield QTL, 2 under both of the fat yield peaks, 8 and 9 under the protein yield peaks, 2 and 6 for the fat per cent peaks and 5 for the protein per cent peak. One SNP in particular, ss61514555:A>C, showed association with 3 of the 5 traits: milk (p = 1.59E-04), fat (p = 6.88E-05) and protein yields (p = 5.76E-05). Overall, combining information from linkage disequilibrium, sire heterozygosity and genetic knowledge of traits enabled the characterization of additional markers with significant associations with milk production traits.
Keyword Canadian Holstein
Candidate markers
Milk production traits
Quantitative trait loci (QTL)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Alliance for Agriculture and Food Innovation
 
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Created: Thu, 09 Feb 2012, 10:32:23 EST by Stephen Moore on behalf of Qld Alliance for Agriculture and Food Innovation