Seasonal variation in peritoneal dialysis-associated peritonitis: A multi-centre registry study

Cho, Yeoungjee, Badve, Sunil V., Hawley, Carmel M., McDonald, Stephen P., Brown, Fiona G., Boudville, Neil, Wiggins, Kathryn J., Bannister, Kym M., Clayton, Philip A. and Johnson, David W. (2012) Seasonal variation in peritoneal dialysis-associated peritonitis: A multi-centre registry study. Nephrology, Dialysis, Transplantation, 27 5: 2028-2036. doi:10.1093/ndt/gfr582


Author Cho, Yeoungjee
Badve, Sunil V.
Hawley, Carmel M.
McDonald, Stephen P.
Brown, Fiona G.
Boudville, Neil
Wiggins, Kathryn J.
Bannister, Kym M.
Clayton, Philip A.
Johnson, David W.
Title Seasonal variation in peritoneal dialysis-associated peritonitis: A multi-centre registry study
Journal name Nephrology, Dialysis, Transplantation   Check publisher's open access policy
ISSN 1460-2385
1460-2385
Publication date 2012-05
Year available 2011
Sub-type Article (original research)
DOI 10.1093/ndt/gfr582
Volume 27
Issue 5
Start page 2028
End page 2036
Total pages 9
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2012
Language eng
Formatted abstract
Background.
The role of seasonal variation in peritoneal dialysis (PD)-related peritonitis has been limited to a few small single-centre studies.

Methods.

Using all 6610 Australian patients receiving PD between 1 October 2003 and 31 December 2008, we evaluated the influence of seasons on peritonitis rates (Poisson regression) and outcomes (multivariable logistic regression).

Results.
The overall rate of peritonitis was 0.59 episodes per patient-year of treatment. Using winter as the reference season, the peritonitis incidence rate ratios (95% confidence interval) for summer, autumn and spring were 1.02 (0.95–1.09), 1.01 (0.94–1.08) and 0.99 (0.92–1.06), respectively. Significant seasonal variations were observed in the rates of peritonitis caused by coagulase-negative Staphylococci (spring and summer peaks), corynebacteria (winter peak) and Gram-negative organisms (summer and autumn peaks). There were trends to seasonal variations in fungal peritonitis (summer and autumn peaks) and pseudomonas peritonitis (summer peak). No significant seasonal variations were observed for other organisms. Peritonitis outcomes did not significantly vary according to season.

Conclusions.
Seasonal variation has no appreciable influence on overall PD peritonitis rates or clinical outcomes. Nevertheless, significant seasonal variations were observed in the rates of peritonitis due to specific microorganisms, which may allow institutions to more precisely target infection control strategies prior to higher risk seasons.
Keyword Bacteria
Fungus
Peritoneal dialysis
Peritonitis
Season
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 6 October 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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Created: Wed, 08 Feb 2012, 12:24:46 EST by Matthew Lamb on behalf of School of Medicine