Population genetic analysis of Y-chromosomal single nucleotide polymorphism in six Chinese populations.

Zhang, Y-L., Yu, M., Chen, F., Xue, Y-L., Ma, Linlin, Huang, X-Y., Zhang, G. Y., Li, P. and Fu, S. (2004) Population genetic analysis of Y-chromosomal single nucleotide polymorphism in six Chinese populations.. Chinese Journal of Medical Genetics, 21 2: 138-143.


Author Zhang, Y-L.
Yu, M.
Chen, F.
Xue, Y-L.
Ma, Linlin
Huang, X-Y.
Zhang, G. Y.
Li, P.
Fu, S.
Title Population genetic analysis of Y-chromosomal single nucleotide polymorphism in six Chinese populations.
Journal name Chinese Journal of Medical Genetics   Check publisher's open access policy
ISSN 1003-9406
Publication date 2004-01-01
Sub-type Article (original research)
Volume 21
Issue 2
Start page 138
End page 143
Total pages 6
Language eng
Abstract Objective: To analyze the genetic polymorphism of 15 single nucleotide polymorphism (SNP) loci on the nonrecombining portion of the Y chromosome in 6 populations in China. Methods: Allelic specific polymerase chain reaction and 2% agarose gel electrophoresis and 6% PAGE were used to analyze the genetic polymorphism of 343 unrelated males, representing 6 populations in China, including Fujian Hans, Sichuan Hans, Mongolian, Hezhen, Sibo and Hui from the South, Northeast and Northwest. Results: Thirty haplogroups were observed, and 3 of them (H15, H16, H18) were seen in all of the six populations. Although the heterozygosity levels of the Hezhen, Mongolian, Sibo populations are similar and those of the other 3 populations (Fujian Hans, Sichuan Hans, Hui) are similar, the pairwise differences among haplogroups are significant. Analysis of molecular variance (AMOVA) and principal component (PC) analysis of the haplogroup distributions suggested highly different allele diversity between group I including Hezhen, Mongolian, Sibo and group I including Hui, Fujian Hans, Sichuan Hans. Conclusion: The above analyses show more significant variance components in Northeast/South populations and clearly reveal the geographic genetic relationship among the six populations in the Northeast/Northwest/South. These results confirm the complexity of the genetic structure of Chinese populations and make a significant contribution for constructing the contemporary human gene pool and tracing genetic dispersal trail from Chinese populations.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Linlin Ma was not affiliated with UQ at time of publication

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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Created: Tue, 07 Feb 2012, 22:37:07 EST by Susan Allen on behalf of Institute for Molecular Bioscience