Polymorphism study of seven SNPs at ADH genes in 15 Chinese populations

Ma, Linlin, Xue, Yali, Liu, Yan, Wang, Zhe, Cui, Xiaobo, Li, Pu and Fu, Songbin (2005) Polymorphism study of seven SNPs at ADH genes in 15 Chinese populations. Hereditas, 142 103-111. doi:10.1111/j.1601-5223.2005.01910.x

Author Ma, Linlin
Xue, Yali
Liu, Yan
Wang, Zhe
Cui, Xiaobo
Li, Pu
Fu, Songbin
Title Polymorphism study of seven SNPs at ADH genes in 15 Chinese populations
Journal name Hereditas   Check publisher's open access policy
ISSN 0018-0661
Publication date 2005-02
Sub-type Article (original research)
DOI 10.1111/j.1601-5223.2005.01910.x
Open Access Status DOI
Volume 142
Start page 103
End page 111
Total pages 9
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
It has been shown that the variants of alcohol dehydrogenase (ADH) genes exhibit great diversities among various populations and are associated with susceptibility to alcoholism. To investigate the distribution of SNPs at ADH genes in Chinese populations and the genetic relationship of these groups, we collected 467 individuals from 15 groups distributing widely from north to south in China and genotyped 7 SNPs at ADH genes respectively. The statistic analyses of allele frequencies, estimated haplotype frequencies, pairwise linkage disequilibrium, AMOVA (analysis of molecular variance), pairwise Fst’, and cluster analysis indicated (1) that six of these seven SNPs showed great variations in the 15 Chinese populations, and three of them (RsaI, SspI, EcoRI), were confirmed to be informative SNPs. However, the causative SNP ADH1B Arg47His confirmed in case-control studies could not act as significant indicator to distinguish bibulous groups from non-bibulous groups in healthy individuals; (2) haplotypes constructed with ADH SNPs could be used as markers to discern different populations in China, and six-allele haplotype “221211” was the most common one defined in present study; (3) on the basis of SNPs analysis of ADH genes, the 15 populations were grouped into northern groups and southern groups. Moreover, the origin relationship among the populations was indicated according to the results of cluster analysis.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Tue, 07 Feb 2012, 12:28:52 EST by Susan Allen on behalf of Institute for Molecular Bioscience