Characterization of the laminin gene family and evolution in zebrafish

Sztal, Tamar, Berger, Silke, Currie, Peter D. and Hall, Thomas E. (2011) Characterization of the laminin gene family and evolution in zebrafish. Developmental Dynamics, 240 2: 422-431. doi:10.1002/dvdy.22537

Author Sztal, Tamar
Berger, Silke
Currie, Peter D.
Hall, Thomas E.
Title Characterization of the laminin gene family and evolution in zebrafish
Journal name Developmental Dynamics   Check publisher's open access policy
ISSN 1058-8388
Publication date 2011-02
Sub-type Article (original research)
DOI 10.1002/dvdy.22537
Volume 240
Issue 2
Start page 422
End page 431
Total pages 10
Place of publication Hoboken, NJ, United States
Publisher John Wiley and Sons
Collection year 2012
Language eng
Formatted abstract
Laminins are essential components of all basement membranes and are fundamental to tissue development and homeostasis. Humans possess at least 16 different heterotrimeric laminin complexes formed through different combinations of alpha, beta, and gamma chains. Individual chains appear to exhibit unique expression patterns, leading to the notion that overlap between expression domains governs the constitution of complexes found within particular tissues. However, the spatial and temporal expression of laminin genes has not been comprehensively analyzed in any vertebrate model to date. Here, we describe the tissue-specific expression patterns of all laminin genes in the zebrafish, throughout embryonic development and into the “post-juvenile” period, which is representative of the adult body form. In addition, we present phylogenetic and microsynteny analyses, which demonstrate that the majority of our zebrafish sequences are orthologous to human laminin genes. Together, these data represent a fundamental resource for the study of vertebrate laminins. Developmental Dynamics 240:422–431, 2011.
Keyword Laminin
In situ hybridization
Integrin-linked kinase (ILK)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 16 times in Scopus Article | Citations
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Created: Tue, 07 Feb 2012, 10:11:05 EST by Susan Allen on behalf of Institute for Molecular Bioscience