Temporal investigation of matrix metalloproteinases and their inhibitors in human cervicovaginal fluid in late pregnancy and labor

Heng, Yujing J., Di Quinzio, Megan K. W., Liong, Stella, Permezel, Michael, Rice, Gregory E. and Georgiou, Harry M. (2012) Temporal investigation of matrix metalloproteinases and their inhibitors in human cervicovaginal fluid in late pregnancy and labor. Reproductive Sciences, 19 1: 55-63. doi:10.1177/1933719111413299


Author Heng, Yujing J.
Di Quinzio, Megan K. W.
Liong, Stella
Permezel, Michael
Rice, Gregory E.
Georgiou, Harry M.
Title Temporal investigation of matrix metalloproteinases and their inhibitors in human cervicovaginal fluid in late pregnancy and labor
Journal name Reproductive Sciences   Check publisher's open access policy
ISSN 1933-7191
1933-7205
Publication date 2012-01
Year available 2011
Sub-type Article (original research)
DOI 10.1177/1933719111413299
Volume 19
Issue 1
Start page 55
End page 63
Total pages 9
Place of publication Thousand Oaks, CA, United States
Publisher Sage Publications
Collection year 2012
Language eng
Abstract Temporal expression of matrix metalloproteinase (MMP)-1, -2, -3, -7, -8, -9, -12, and -13, and tissue inhibitors of metalloproteinases (TIMPs)-1 and -2 in human cervicovaginal fluid (CVF) in term pregnancy and labor was investigated. Term parous women provided CVF samples that were grouped into labor, 1 to 3, 6 to 8, and 12 to 16 days before labor onset. Both MMPs and TIMPs (n = 60) were quantified using multiplex solution array and enzyme-linked immunosorbent assays, respectively. Further analysis of TIMP-1 (n = 180) was undertaken. All MMPs and TIMPs except MMP-12 and -13 were detected in the CVF. Matrix metalloproteinase 7, TIMP-1, and TIMP-2 were significantly increased in labor. Tissue inhibitors of metalloproteinase 1 was significantly increased up to 7 days before spontaneous labor onset. The data suggest a role of MMP-7 in the remodeling and rupture of fetal membranes and may reflect the homeostatic regulation of extracellular matrix remodeling of MMP-7 by TIMP-1 and TIMP-2.
Keyword Cervicovaginal fluid
Labor
Matrix metalloproteinases
Pregnancy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online before print November 3, 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2012 Collection
 
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