Influence of membrane ion channel in pituitary somatotrophs by hypothalamic regulators

Yang, Seung-Kwon, Steyn, Frederik and Chen, Chen (2012) Influence of membrane ion channel in pituitary somatotrophs by hypothalamic regulators. Cell Calcium, 51 3-4: 231-239. doi:10.1016/j.ceca.2011.12.005

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Author Yang, Seung-Kwon
Steyn, Frederik
Chen, Chen
Title Influence of membrane ion channel in pituitary somatotrophs by hypothalamic regulators
Journal name Cell Calcium   Check publisher's open access policy
ISSN 0143-4160
1532-1991
Publication date 2012-03
Sub-type Article (original research)
DOI 10.1016/j.ceca.2011.12.005
Open Access Status
Volume 51
Issue 3-4
Start page 231
End page 239
Total pages 9
Place of publication Kidlington, U.K.
Publisher Churchill Livingstone
Collection year 2013
Language eng
Formatted abstract
The secretion of growth hormone (GH) from somatotrophs located within the anterior pituitary gland is stimulated by endogenous hypothalamic growth hormone-releasing hormone (GHRH) and the GH secretagogue (GHS) ghrelin, and inhibited by somatotropin-releasing inhibitory factor (SRIF, also known as somatostatin). These factors bind to specific G-protein-coupled receptors on the cell membrane, and directly or indirectly modify the properties of ion channels and second messenger systems. Ultimately this results in a change in intracellular free Ca2+ concentration ([Ca2+]i) and the secretion of GH. Somatotrophs possess a variety of ion channels on their membranes, and modification of these ion channels, especially Ca2+, K+, and Na+ channels, is tightly linked to intracellular Ca2+ levels and therefore hormone secretion. Various issues regarding receptor distribution, role of ion channels, alteration of membrane potential, and involvement of intracellular signaling system in the control of GH secretion are discussed in this review. In particular, this work will focus on ion channels and [Ca2+]i in somatotrophs.
Keyword Growth hormone
Ion channels
Somatotroph
GHRH
SRIF
Ghrelin
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Authors prepress title: "Influence of Membrane Ion Channel in Pituitary Somato-trophs by Hypothalamic Regulators". Available online 12 January 2012. Special issue on Calcium Signalling in Neuroendocrine Cells.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Biomedical Sciences Publications
 
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Created: Mon, 06 Feb 2012, 11:46:45 EST by Dr Sean Seung-Kwon Yang on behalf of School of Biomedical Sciences