Molecular structural differences between type-2-diabetic and healthy glycogen

Sullivan, Mitchell A., Li, Jiong, Li, Chuanzhou, Vilaplana, Francisco, Stapleton, David, Gray-Weale, Angus A., Bowen, Stirling, Zheng, Ling and Gilbert, Robert G. (2011) Molecular structural differences between type-2-diabetic and healthy glycogen. Biomacromolecules, 12 6: 1983-1986. doi:10.1021/bm2006054


Author Sullivan, Mitchell A.
Li, Jiong
Li, Chuanzhou
Vilaplana, Francisco
Stapleton, David
Gray-Weale, Angus A.
Bowen, Stirling
Zheng, Ling
Gilbert, Robert G.
Title Molecular structural differences between type-2-diabetic and healthy glycogen
Journal name Biomacromolecules   Check publisher's open access policy
ISSN 1525-7797
1526-4602
Publication date 2011-06-13
Sub-type Article (original research)
DOI 10.1021/bm2006054
Volume 12
Issue 6
Start page 1983
End page 1986
Total pages 4
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2012
Language eng
Abstract Glycogen is a highly branched glucose polymer functioning as a glucose buffer in animals. Multiple-detector size exclusion chromatography and fluorophore-assisted carbohydrate electrophoresis were used to examine the structure of undegraded native liver glycogen (both whole and enzymatically debranched) as a function of molecular size, isolated from the livers of healthy and db/db mice (the latter a type 2 diabetic model). Both the fully branched and debranched levels of glycogen structure showed fundamental differences between glycogen from healthy and db/db mice. Healthy glycogen had a greater population of large particles, with more α particles (tightly linked assemblages of smaller β particles) than glycogen from db/db mice. These structural differences suggest a new understanding of type 2 diabetes.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published under Communications

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Centre for Nutrition and Food Sciences Publications
 
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Created: Thu, 02 Feb 2012, 12:26:58 EST by Professor Bob Gilbert on behalf of School of Chemistry & Molecular Biosciences