Pharmacological treatment of neonatal opiate withdrawal: between the devil and the deep blue sea

Liu, Anthony, Bjorkman, Tracey, Stewart, Caroline and Nanan, Ralph (2011) Pharmacological treatment of neonatal opiate withdrawal: between the devil and the deep blue sea. International Journal of Pediatrics, 2011 935631.1-935631.5. doi:10.1155/2011/935631

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Author Liu, Anthony
Bjorkman, Tracey
Stewart, Caroline
Nanan, Ralph
Title Pharmacological treatment of neonatal opiate withdrawal: between the devil and the deep blue sea
Journal name International Journal of Pediatrics   Check publisher's open access policy
ISSN 1687-9740
1687-9759
Publication date 2011
Sub-type Article (original research)
DOI 10.1155/2011/935631
Open Access Status DOI
Volume 2011
Start page 935631.1
End page 935631.5
Total pages 5
Place of publication New York, United States
Publisher Hindawi Publishing Corporation
Collection year 2012
Language eng
Abstract Illicit drug use with opiates in pregnancy is a major global health issue with neonatal withdrawal being a common complication. Morphine is the main pharmacological agent administered for the treatment of neonatal withdrawal. In the past, morphine has been considered by and large inert in terms of its long-term effects on the central nervous system. However, recent animal and clinical studies have demonstrated that opiates exhibit significant effects on the growing brain. This includes direct dose-dependent effects on reduction in brain size and weight, protein, DNA, RNA, and neurotransmitters—possibly as a direct consequence of a number of opiate-mediated systems that influence neural cell differentiation, proliferation, and apoptosis. At this stage, we are stuck between the devil and the deep blue sea. There are no real alternatives to pharmacological treatment with opiates and other drugs for neonatal opiate withdrawal and opiate addiction in pregnant women. However, pending further rigorous studies examining the potential harmful effects of opiate exposure in utero and the perinatal period, prolonged use of these agents in the neonatal period should be used judiciously, with caution, and avoided where possible.
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Non HERDC
 
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Created: Thu, 02 Feb 2012, 10:51:07 EST by Roheen Gill on behalf of UQ Centre for Clinical Research