Genome-wide association studies of female reproduction in tropically adapted beef cattle

Hawken, R. J., Zhang, Y. D., Fortes, M. R. S., Collis, E., Barris, W. C., Corbet, N. J., Williams, P. J., Fordyce, G., Holroyd, R. G., Walkley, J. R. W, Barendse, W., Johnston, D. J., Prayaga, K. C., Tier, B., Reverter, A. and Lehnert S. A. (2012) Genome-wide association studies of female reproduction in tropically adapted beef cattle. Journal of Animal Science, 90 5: 1398-1410. doi:10.2527/jas.2011-4410

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Author Hawken, R. J.
Zhang, Y. D.
Fortes, M. R. S.
Collis, E.
Barris, W. C.
Corbet, N. J.
Williams, P. J.
Fordyce, G.
Holroyd, R. G.
Walkley, J. R. W
Barendse, W.
Johnston, D. J.
Prayaga, K. C.
Tier, B.
Reverter, A.
Lehnert S. A.
Title Genome-wide association studies of female reproduction in tropically adapted beef cattle
Journal name Journal of Animal Science   Check publisher's open access policy
ISSN 0021-8812
Publication date 2012-05
Year available 2011
Sub-type Article (original research)
DOI 10.2527/jas.2011-4410
Volume 90
Issue 5
Start page 1398
End page 1410
Total pages 30
Place of publication Savoy, IL, United States
Publisher American Society of Animal Science
Collection year 2012
Language eng
Formatted abstract
The genetics of reproduction is poorly understood because the heritabilities of traits currently recorded are low. In order to elucidate the genetics underlying reproduction in beef cattle we performed a genome wide association study using the bovine SNP50 chip in two tropically adapted beef cattle breeds; Brahman and Tropical Composites. Here we present the results for three female reproduction traits: (1) Age at puberty, defined as age in days at first observed corpus luteum (CL) following frequent ovarian ultrasound scans (AGECL); (2) the post partum anoestrous interval, measured as the number of days from calving to first ovulation post partum (first re-breeding interval, PPAI) and (3) The occurrence of the first post-partum ovulation prior to weaning in the first re-breeding period (PW), defined from PPAI. In addition, correlated traits such as weight, height, serum IGF1 concentration, condition score and fatness were also examined. In the Brahman and Tropical Composite cattle, 169 (false positive rate (FPR) = 0.262) and 84 (FPR = 0.581) SNP, respectively, were significant (P < 0.001) for AGECL. In Brahman, 41% of these significant markers mapped to a single chromosomal region on BTA14. In Tropical Composites, 16% of these significant markers were located on BTA5. For PPAI, 66 (FPR = 0.67) and 113 (FPR = 0.432) SNP were significant (P < 0.001) in Brahman and Tropical Composite respectively, while for PW, 68 (FPR = 0.64) and 113 (FPR = 0.432) SNP were significant. In Tropical Composites, the largest concentration of PPAI markers were located on BTA5 (19% (PPAI) and 23% (PW)), and BTA16 (17% (PPAI) and 18% (PW)). In Brahman cattle the largest concentration of markers for post partum anoestrus was located on BTA 3 (14% for PPAI and PW) and BTA14 (17% PPAI). Very few of the significant markers for female reproduction traits for the Brahman and Tropical Composite breeds were located in the same chromosomal regions. However, fatness and live weight traits as well as serum IGF1 concentration were found to be associated with identical genome regions within and between breeds. Clusters of SNP associated with multiple traits were located on BTA14 in Brahman and BTA5 in Tropical Composites.
Keyword Beef cattle
Genome-wide association study
Pleiotropic effects
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online before print November 18, 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Queensland Alliance for Agriculture and Food Innovation
School of Veterinary Science Publications
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Citation counts: TR Web of Science Citation Count  Cited 54 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 59 times in Scopus Article | Citations
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Created: Thu, 02 Feb 2012, 08:51:10 EST by Dr Geoffry Fordyce on behalf of Qld Alliance for Agriculture and Food Innovation