Preformed selenoesters enable rapid native chemical ligation at intractable sites

Durek, Thomas and Alewood, Paul F. (2011) Preformed selenoesters enable rapid native chemical ligation at intractable sites. Angewandte Chemie International Edition, 50 50: 12042-12045. doi:10.1002/anie.201105512


Author Durek, Thomas
Alewood, Paul F.
Title Preformed selenoesters enable rapid native chemical ligation at intractable sites
Journal name Angewandte Chemie International Edition   Check publisher's open access policy
ISSN 1433-7851
1521-3773
Publication date 2011-12
Sub-type Article (original research)
DOI 10.1002/anie.201105512
Volume 50
Issue 50
Start page 12042
End page 12045
Total pages 4
Place of publication Weinheim, Germany
Publisher Wiley - VCH Verlag
Collection year 2012
Language eng
Formatted abstract
Going pro: The first facile Pro–Cys ligation using a preformed prolyl selenoester is reported (see scheme; P=peptide). In a comparative study of peptide selenoesters in native chemical ligation peptide α-selenoesters are shown to be superior acyl donors and result in rate enhancements of at least two orders of magnitude when compared to the well-established peptide α-thioesters. This method permits rapid chemical ligation even at previously intractable sites, such as Pro-Cys.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Tue, 31 Jan 2012, 11:34:53 EST by Susan Allen on behalf of Institute for Molecular Bioscience