The early development of the kidney and implications for future health

Hoy, W.E., Ingelfinger, J.R., Hallan, S., Hughson, M.D., Mott, S.A. and Bertram, J.F. (2010) The early development of the kidney and implications for future health. Journal of Developmental Origins of Health and Disease, 1 4: 216-233. doi:10.1017/S204017441000022X


Author Hoy, W.E.
Ingelfinger, J.R.
Hallan, S.
Hughson, M.D.
Mott, S.A.
Bertram, J.F.
Title The early development of the kidney and implications for future health
Journal name Journal of Developmental Origins of Health and Disease   Check publisher's open access policy
ISSN 2040-1744
2040-1752
Publication date 2010-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1017/S204017441000022X
Volume 1
Issue 4
Start page 216
End page 233
Total pages 18
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Language eng
Abstract The kidney is a relative newcomer among the organ systems for which relevance of the developmental origins hypothesis has been explored. Nephrology is a young discipline, to which epidemiologic principles have only been recently applied, and although the availability of renal replacement therapy in westernized countries has created a large group of people with end stage renal disease who can be studied in retrospect, attention has only recently focused on the vastly greater numbers of people with earlier stages of chronic kidney disease, and their accentuated cardiovascular risk. Development of the human kidney is influenced by genetic and epigenetic factors, by maternal nutritional status, maternal stature and the intrauterine environment, the length of gestation, the neonatal course and by postnatal nutrition. Many factors that influence kidney development also influence other developing organ systems. This paper summarizes some of the current knowledge and the implications of kidney development for future health, much of which have also been described in other recent reviews.
Keyword Kidney development
Low-Birth-Weight
Maternal Protein Restriction
Australian Aboriginal Community
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: ERA 2012 Admin Only
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