Piperine attenuates cardiovascular, liver and metabolic changes in high carbohydrate, high fat-fed rats

Diwan, Vishal, Poudyal, Hemant and Brown, Lindsay (2012) Piperine attenuates cardiovascular, liver and metabolic changes in high carbohydrate, high fat-fed rats. Cell Biochemistry and Biophysics, 67 2: 297-304. doi:10.1007/s12013-011-9306-1

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Author Diwan, Vishal
Poudyal, Hemant
Brown, Lindsay
Title Piperine attenuates cardiovascular, liver and metabolic changes in high carbohydrate, high fat-fed rats
Journal name Cell Biochemistry and Biophysics   Check publisher's open access policy
ISSN 1085-9195
1559-0283
Publication date 2012
Year available 2011
Sub-type Article (original research)
DOI 10.1007/s12013-011-9306-1
Volume 67
Issue 2
Start page 297
End page 304
Total pages 8
Place of publication Totowa, NJ, U.S.A.
Publisher Humana Press
Collection year 2012
Language eng
Formatted abstract
Black pepper is used worldwide to enhance food flavor. We investigated dietary supplementation with piperine, the active principle of black pepper, to high carbohydrate, high fat (HCHF) diet-fed rats as a model of human metabolic syndrome. Rats were fed with either HCHF diet (carbohydrate, 52%; fat, 24%; 25% fructose in drinking water) or cornstarch (CS) diet for a total of 16 weeks. Diets of the treatment groups (CS + piperine and HCHF + piperine) were supplemented with piperine for the last 8 weeks of this protocol. After 16 weeks, rats fed with HCHF diet developed hypertension, elevated oxidative stress and inflammation-induced cardiac changes (infiltration of inflammatory cells in heart, increase in count and degranulation of mast cells in heart, cardiac fibrosis and increase in ventricular stiffness), reduced responsiveness of aortic rings, impaired glucose tolerance, abdominal obesity together with liver fibrosis, fat deposition and increased plasma liver enzymes. Supplementation with piperine (375 mg/kg food; approximately 30 mg/kg/day) in HCHF-fed rats normalized blood pressure, improved glucose tolerance and reactivity of aortic rings, reduced plasma parameters of oxidative stress and inflammation, attenuated cardiac and hepatic inflammatory cell infiltration and fibrosis and improved liver function. These changes clearly suggest that piperine reduces symptoms of human metabolic syndrome in HCHF-fed rats by reducing inflammation and oxidative stress.
Keyword Piperine
Metabolic syndrome
Rats
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 30 October 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biomedical Sciences Publications
 
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Created: Fri, 27 Jan 2012, 08:47:43 EST by Bacsweet Kaur on behalf of School of Biomedical Sciences