Breath ammonia and trimethylamine allow real-time monitoring of haemodialysis efficacy

Endre, Z. H., Pickering, J. W., Storer, M. K., Hu, W. -P., Moorhead, K. T., Allardyce, R., McGregor, D. O. and Scotter, J. M. (2011) Breath ammonia and trimethylamine allow real-time monitoring of haemodialysis efficacy. Physiological Measurement, 32 1: 115-130. doi:10.1088/0967-3334/32/1/008

Author Endre, Z. H.
Pickering, J. W.
Storer, M. K.
Hu, W. -P.
Moorhead, K. T.
Allardyce, R.
McGregor, D. O.
Scotter, J. M.
Title Breath ammonia and trimethylamine allow real-time monitoring of haemodialysis efficacy
Journal name Physiological Measurement   Check publisher's open access policy
ISSN 0967-3334
Publication date 2011-01
Year available 2010
Sub-type Article (original research)
DOI 10.1088/0967-3334/32/1/008
Volume 32
Issue 1
Start page 115
End page 130
Total pages 16
Place of publication Bristol, United Kingdom
Publisher Institute of Physics Publishing
Collection year 2012
Language eng
Formatted abstract
Non-invasive monitoring of breath ammonia and trimethylamine using Selected-ion-flow-tube mass spectroscopy (SIFT-MS) could provide a real-time alternative to current invasive techniques. Breath ammonia and trimethylamine were monitored by SIFT-MS before, during and after haemodialysis in 20 patients. In 15 patients (41 sessions), breath was collected hourly into Tedlar bags and analysed immediately (group A). During multiple dialyses over 8 days, five patients breathed directly into the SIFT-MS analyser every 30 min (group B). Pre- and post-dialysis direct breath concentrations were compared with urea reduction, Kt/V and creatinine concentrations. Dialysis decreased breath ammonia, but a transient increase occurred mid treatment in some patients. Trimethylamine decreased more rapidly than reported previously. Pre-dialysis breath ammonia correlated with pre-dialysis urea in group B (r2 = 0.71) and with change in urea (group A, r2 = 0.24; group B, r2 = 0.74). In group B, ammonia correlated with change in creatinine (r2 = 0.35), weight (r2 = 0.52) and Kt/V (r2 = 0.30). The ammonia reduction ratio correlated with the urea reduction ratio (URR) (r2 = 0.42) and Kt/V (r2 = 0.38). Pre-dialysis trimethylamine correlated with Kt/V (r2 = 0.21), and the trimethylamine reduction ratio with URR (r2 = 0.49) and Kt/V (r2 = 0.36). Real-time breath analysis revealed previously unmeasurable differences in clearance kinetics of ammonia and trimethylamine. Breath ammonia is potentially useful in assessment of dialysis efficacy.
Keyword Kidney
Selected-ion-flow-tube mass spectroscopy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published 8 December 2010 Online at

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Earth Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 30 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 25 Jan 2012, 15:32:23 EST by Wan-Ping Hu on behalf of School of Earth Sciences