Microscopic diffusivity compartmentation in formalin-fixed prostate tissue

Bourne, Roger M., Kurniawan, Nyoman, Cowin, Gary, Stait-Gardner, Timothy, Sved, Paul, Watson, Geoffrey and Price, William S. (2012) Microscopic diffusivity compartmentation in formalin-fixed prostate tissue. Magnetic Resonance in Medicine, 68 2: 614-620. doi:10.1002/mrm.23244

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Author Bourne, Roger M.
Kurniawan, Nyoman
Cowin, Gary
Stait-Gardner, Timothy
Sved, Paul
Watson, Geoffrey
Price, William S.
Title Microscopic diffusivity compartmentation in formalin-fixed prostate tissue
Journal name Magnetic Resonance in Medicine   Check publisher's open access policy
ISSN 0740-3194
1522-2594
Publication date 2012-08
Year available 2011
Sub-type Article (original research)
DOI 10.1002/mrm.23244
Open Access Status File (Author Post-print)
Volume 68
Issue 2
Start page 614
End page 620
Total pages 7
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2012
Language eng
Formatted abstract
MR microimaging at 16.4 T with 40-μm isotropic voxels was used to investigate compartmentation of water diffusion in formalin-fixed prostate tissue. Ten tissue samples (∼ 28 mm3 each) from five organs were imaged. The mean diffusivity of epithelial, stromal, and ductal/acinar compartments was estimated by two methods: (1) manual region of interest selection and (2) Gaussian fitting of voxel diffusivity histograms. For the region of interest-method, the means of the tissue sample compartment diffusivities were significantly different (P < 0.001): 0.54 ± 0.05 μm2/ms for epithelium-containing voxels, 0.91 ± 0.17 μm2/ms for stroma, and 2.20 ± 0.04 μm2/ms for saline-filled ducts. The means from the histogram method were also significantly different (P < 0.001): 0.45 ± 0.08 μm2/ms for epithelium-containing voxels, 0.83 ± 0.16 μm2/ms for stroma, 2.21 ± 0.02 μm2/ms for duct. Estimated partial volumes of epithelial, stromal, and ductal/acinar compartments in a “tissue only” subvolume of each sample were significantly different (P < 0.02) between cancer and normal tissue for all three compartments. It is concluded that the negative correlation between apparent diffusion coefficient and cancer Gleason grade observed in vivo results from an increase of partial volume of epithelial tissue and concomitant decrease of stromal tissue and ductal space.
Keyword Diffusion
Microimaging
Prostate
Compartmentation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 28 December 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Centre for Advanced Imaging Publications
 
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Created: Tue, 24 Jan 2012, 10:10:10 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging