Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors

Luo, Xiao, Hutley, Louise J., Webster, Julie A., Kim, Yu-Hee, Liu, Dong-Fang, Newell, Felicity S., Widberg, Charlotte H., Bachmann, Anthony, Turner, Nigel, Schmitz-Peiffer, Carsten, Prins, Johannes B., Yang, Gong-She and Whitehead, Jonathan P. (2012) Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors. Diabetes, 61 1: 124-136.

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Author Luo, Xiao
Hutley, Louise J.
Webster, Julie A.
Kim, Yu-Hee
Liu, Dong-Fang
Newell, Felicity S.
Widberg, Charlotte H.
Bachmann, Anthony
Turner, Nigel
Schmitz-Peiffer, Carsten
Prins, Johannes B.
Yang, Gong-She
Whitehead, Jonathan P.
Title Identification of BMP and activin membrane-bound inhibitor (BAMBI) as a potent negative regulator of adipogenesis and modulator of autocrine/paracrine adipogenic factors
Journal name Diabetes   Check publisher's open access policy
ISSN 0012-1797
1939-327X
Publication date 2012-01
Sub-type Article (original research)
DOI 10.2337/db11-0998
Volume 61
Issue 1
Start page 124
End page 136
Total pages 13
Place of publication Alexandria, VA, United States
Publisher American Diabetes Association
Collection year 2013
Language eng
Formatted abstract Adipose tissue dysfunction underpins the association of obesity with type 2 diabetes. Adipogenesis is required for the maintenance of adipose tissue function. It involves the commitment and subsequent differentiation of preadipocytes and is coordinated by autocrine, paracrine, and endocrine factors. We previously reported that fibroblast growth factor-1 (FGF-1) primes primary human preadipocytes and Simpson Golabi Behmel syndrome (SGBS) preadipocytes and increases adipogenesis through a cascade involving extracellular signal-related kinase 1/2 (ERK1/2). Here, we aimed to use the FGF-1 system to identify novel adipogenic regulators. Expression profiling revealed bone morphogenetic protein (BMP) and activin membrane-bound inhibitor (BAMBI) as a putative FGF-1 effector. BAMBI is a transmembrane protein and modulator of paracrine factors that regulate adipogenesis, including transforming growth factor (TGF) superfamily members (TGF-β and BMP) and Wnt. Functional investigations established BAMBI as a negative regulator of adipogenesis and modulator of the anti- and proadipogenic effects of Wnt3a, TGF-β1, and BMP-4. Further studies showed that BAMBI expression levels are decreased in a mouse model of diet-induced obesity. Collectively, these findings establish BAMBI as a novel, negative regulator of adipogenesis that can act as a nexus to integrate multiple paracrine signals to coordinate adipogenesis. Alterations in BAMBI may play a role in the (patho)physiology of obesity, and manipulation of BAMBI may present a novel therapeutic approach to improve adipose tissue function.
Keyword Growth Factor Beta
Human Adipocyte Differentiation
Bone Morphogenetic Protein
Adipose Tissue
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Medicine Publications
UQ Diamantina Institute Publications
 
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