Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study

Hollams, E.M., Hart, P.H., Holt, B.J., Serralha, M., Parsons, F., de Klerk, N.H., Zhang, G., Sly, P.D. and Holt, P.G. (2011) Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study. European Respiratory Journal, 38 6: 1320-1327. doi:10.1183/09031936.00029011

Author Hollams, E.M.
Hart, P.H.
Holt, B.J.
Serralha, M.
Parsons, F.
de Klerk, N.H.
Zhang, G.
Sly, P.D.
Holt, P.G.
Title Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study
Journal name European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
Publication date 2011-12
Sub-type Article (original research)
DOI 10.1183/09031936.00029011
Volume 38
Issue 6
Start page 1320
End page 1327
Total pages 8
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Collection year 2012
Language eng
Abstract Vitamin D has been linked in some studies with atopy- and asthma-associated phenotypes in children with established disease, but its role in disease inception at the community level is less clear. The aim of the present study was to investigate associations between vitamin D status and biological signatures indicative of allergy and asthma development in children aged 6 and 14 years in Perth, WA, Australia (latitude 32° S). Serum vitamin D was assayed in 989 6-yr-olds and 1,380 14-yr-olds from an unselected community birth cohort; 689 subjects were assessed at both ages. Vitamin D levels were assessed as a risk modifier for respiratory and allergic outcomes at both ages, using previously ascertained phenotypic data. The predictive value of vitamin D levels at age 6 yrs for development of clinical phenotypes at age 14 yrs was also examined. Serum vitamin D levels in children of both ages were negatively associated with concurrent allergic phenotypes; sex stratification revealed that this association was restricted mainly to males. Furthermore, vitamin D levels at age 6 yrs were significant predictors of subsequent atopy/asthma-associated phenotypes at age 14 yrs. In an unselected community setting, children (particularly males) with inadequate vitamin D are at increased risk of developing atopy, and subsequently bronchial hyperresponsiveness (BHR) and asthma. In a large unselected cohort, males with inadequate vitamin D at 6 and 14 yrs of age had increased atopy and BHR. Low vitamin D at age 6 yrs was a predictor of atopy and asthma at 14 yrs of age.
Keyword Asthma
Bronchial hyperresponsiveness
Male bias
Raine Study
Vitamin D
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 12 May 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
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