Migrating Schistosoma japonicum schistosomula induce an innate immune response and wound healing in the murine lung

Burke, Melissa L., McGarvey, Laken, McSorley, Henry J., Bielefeldt-Ohmann, Helle, McManus, Donald P. and Gobert, Geoffrey N. (2011) Migrating Schistosoma japonicum schistosomula induce an innate immune response and wound healing in the murine lung. Molecular Immunology, 49 1-2: 191-200. doi:10.1016/j.molimm.2011.08.014


Author Burke, Melissa L.
McGarvey, Laken
McSorley, Henry J.
Bielefeldt-Ohmann, Helle
McManus, Donald P.
Gobert, Geoffrey N.
Title Migrating Schistosoma japonicum schistosomula induce an innate immune response and wound healing in the murine lung
Journal name Molecular Immunology   Check publisher's open access policy
ISSN 0161-5890
1872-9142
Publication date 2011-10
Sub-type Article (original research)
DOI 10.1016/j.molimm.2011.08.014
Volume 49
Issue 1-2
Start page 191
End page 200
Total pages 10
Place of publication Oxford, England, U. K.
Publisher Pergamon
Collection year 2012
Language eng
Formatted abstract
The migrating schistosomulum is an important stage of the schistosome lifecycle and represents a key target for elimination of infection by natural and vaccine-induced host immune responses. To gain a better understanding of how schistosomes initiate a primary host immune response we have characterised the host lung response to migrating Schistosoma japonicum schistosomula using a combination of
histopathology, microarray analysis and real-time PCR. Our findings indicate that the early pulmonary response to these migrating larvae is characteristic of innate inflammation and wound healing. This response is associated with significant up-regulation of several genes with immunoregulatory function including Ch25h, Hmox1 and Retnla which may act to control the nature or magnitude of the inflammatory response to the migrating schistosomula, promoting both parasite and host survival. These findings contribute to our understanding of host–parasite interactions associated with schistosome and, especially,  S. japonicum infection, and may aid the future design of novel vaccines that target the lung stage
schistosomulum.
Keyword Microarray
Schistosoma japonicum
Schistosomula
Lung
Primary immune response
Microvascular Endothelial-Cells
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Received 8 July 2011. Received in revised form 10 August 2011 Accepted 18 August 2011. Available online 13 September 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Veterinary Science Publications
 
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