A photon-driven micromotor can direct nerve fibre growth

Wu, Tao, Nieminen, Timo A., Mohanty, Samarendra, Miotke, Jill, Meyer, Ronald L., Rubinsztein-Dunlop, Halina and Berns, Michael W. (2012) A photon-driven micromotor can direct nerve fibre growth. Nature Photonics, 6 1: 62-67. doi:10.1038/NPHOTON.2011.287

Author Wu, Tao
Nieminen, Timo A.
Mohanty, Samarendra
Miotke, Jill
Meyer, Ronald L.
Rubinsztein-Dunlop, Halina
Berns, Michael W.
Title A photon-driven micromotor can direct nerve fibre growth
Journal name Nature Photonics   Check publisher's open access policy
ISSN 1749-4885
Publication date 2012-01
Year available 2011
Sub-type Article (original research)
DOI 10.1038/NPHOTON.2011.287
Volume 6
Issue 1
Start page 62
End page 67
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2012
Language eng
Abstract Axonal path-finding is important in the development of the nervous system, nerve repair and nerve regeneration. The behaviour of the growth cone at the tip of the growing axon determines the direction of axonal growth and migration. We have developed an optical-based system to control the direction of growth of individual axons (nerve fibres) using laser-driven spinning birefringent spheres. One or two optical traps position birefringent beads adjacent to growth cones of cultured goldfish retinal ganglion cell axons. Circularly polarized light with angular momentum causes the trapped bead to spin. This creates a localized microfluidic flow generating an estimated 0.17 pN shear force against the growth cone that turns in response to the shear. The direction of axonal growth can be precisely manipulated by changing the rotation direction and position of this optically driven micromotor. A physical model estimating the shear force density on the axon is described.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 04 December 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
Official 2012 Collection
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Citation counts: TR Web of Science Citation Count  Cited 36 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 41 times in Scopus Article | Citations
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