Cellular transport pathways of polymer coated gold nanoparticles

Lin, I-Chun, Liang, Mingtao, Liu, Tzu-Yu, Monteiro, Michael J. and Toth, Istvan (2012) Cellular transport pathways of polymer coated gold nanoparticles. Nanomedicine, 8 1: 8-11. doi:10.1016/j.nano.2011.09.014

Author Lin, I-Chun
Liang, Mingtao
Liu, Tzu-Yu
Monteiro, Michael J.
Toth, Istvan
Title Cellular transport pathways of polymer coated gold nanoparticles
Journal name Nanomedicine   Check publisher's open access policy
ISSN 1743-5889
Publication date 2012-01-08
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.nano.2011.09.014
Volume 8
Issue 1
Start page 8
End page 11
Total pages 4
Place of publication London, United Kingdom
Publisher Future Medicine
Collection year 2012
Language eng
Abstract The different transport pathways of 5-nm polymer-coated gold nanoparticles (AuNPs) crossing epithelial Caco-2 cell monolayers were explored. We found that the majority of cationic and neutral AuNPs depended heavily on endocytosis for cellular uptake and transport, and the anionic charged nanoparticles trafficked preferentially through the tight junctions (i.e., a paracellular pathway). The current study demonstrates that the surface chemistry of neutral polymer coatings dictate the trafficking through Caco-2 cell monolayers; poly(ethylene glycol)-coated AuNPs traffic via an endocytosis pathway assisted by microtubules; poly(2,3-hydroxy-propylacrylamide)-coated AuNPs traffic via endocytosis but assisted by other nonmicrotubular pathways. The AuNPs coated with poly(N-isopropylacrylamide) (hydrophobic above the lower critical solution temperature of 32°C) traffic via either the microtubule-assisted endocytosis pathway or the paracellular pathway depending on the temperature. This knowledge will aid in the future of the design of nanoparticles as potential oral drug carriers.
Keyword Polymer-coated nanoparticles
Gold nanoparticles
Caco-2 cells
Cellular transport
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 21 October 2011.

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Created: Thu, 19 Jan 2012, 09:34:57 EST by Professor Istvan Toth on behalf of School of Pharmacy