HLA typing in Vogt-Koyanagi-Harada syndrome in north Indian patients

Gupta, Amod, Kamal, Shivali, Gupta, Vishali, Bambery, Pradeep and Kaura, Babita (2007) HLA typing in Vogt-Koyanagi-Harada syndrome in north Indian patients. Ocular Immunology and Inflammation, 15 2: 89-97. doi:10.1080/09273940601186727

Author Gupta, Amod
Kamal, Shivali
Gupta, Vishali
Bambery, Pradeep
Kaura, Babita
Title HLA typing in Vogt-Koyanagi-Harada syndrome in north Indian patients
Journal name Ocular Immunology and Inflammation   Check publisher's open access policy
ISSN 0927-3948
Publication date 2007-03
Sub-type Article (original research)
DOI 10.1080/09273940601186727
Volume 15
Issue 2
Start page 89
End page 97
Total pages 9
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Formatted abstract
Purpose: To report the HLA profile of VKH patients from India. Method: Forty-one patients and 50 controls were studied. Phenotyping using a lymphocytotoxicity assay was done for HLA-A and -B. DNA-based sequence-specific low resolution typing was done for HLA-DR and -DQ loci. Results: HLA-A9 was over-represented in the patient population (p = 0.01), whereas HLA-A11 (p = 0.03) and HLA-DRB1∗13 (p = 0.007) were found to be underrepresented. The frequency of HLA-DRB1∗04 was 14.6% and 10% in the patient population and controls, respectively. The HLA-DQ frequencies did not differ significantly between patients and controls. Conclusion: Unlike that reported in most populations, we did not find a significant association between HLA-DRB104 and our patient population.
Keyword Human leukocyte antigens
Vogt-Koyanagi-Harada syndrome
Southern California
Strong association
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
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