Role of anti-tubercular therapy in uveitis with latent/manifest tuberculosis

Bansal, Reema, Gupta, Amod, Gupta, Vishali, Dogra, Mangat Ram, Bambery, Pradeep and Arora, Sunil Kumar (2008) Role of anti-tubercular therapy in uveitis with latent/manifest tuberculosis. American Journal of Ophthalmology, 146 5: 772-779. doi:10.1016/j.ajo.2008.06.011

Author Bansal, Reema
Gupta, Amod
Gupta, Vishali
Dogra, Mangat Ram
Bambery, Pradeep
Arora, Sunil Kumar
Title Role of anti-tubercular therapy in uveitis with latent/manifest tuberculosis
Journal name American Journal of Ophthalmology   Check publisher's open access policy
ISSN 0002-9394
Publication date 2008-11
Sub-type Article (original research)
DOI 10.1016/j.ajo.2008.06.011
Volume 146
Issue 5
Start page 772
End page 779
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Abstract PURPOSE: To assess the role of anti-tubercular therapy in uveitis with latent/manifest tuberculosis (TB). DESIGN: Retrospective, interventional case series. METHODS: A total of 360 patients from uveitis clinic with following inclusion criteria were studied: 1) complete clinical records of visual acuity, slit-lamp biomicroscopic examination, intraocular pressure, complications if any, and treatment records at the baseline and at all follow-up visits; 2) a documented positive tuberculin skin test (10 mm of induration or more) at 48 to 72 hours; 3) evidence of active uveitis, i.e., cellular reaction in the anterior chamber with or without keratic precipitates, and/or active vitreous inflammation, retinal vasculitis, choroiditis, or neuroretinitis; 4) all known causes of infectious uveitis except TB and known noninfectious uveitic syndromes ruled out; and 5) a minimum one year of follow-up from the initiation of treatment. Of these, 216 patients (Group A) received four-drug anti-tubercular therapy and corticosteroids, and 144 patients (Group B) received corticosteroids alone. The main outcome measure was recurrence of inflammation after minimum six months of initiating treatment in each group. RESULTS: Recurrences reduced significantly (P < .001) in Group A (15.74%) as compared to Group B (46.53%) over a median follow-up of 24 and 31 months, respectively. The patients treated with anti-tubercular therapy with corticosteroids had decreased risk of developing recurrence of uveitis by approximately two-thirds as compared to those treated with corticosteroids alone. CONCLUSION: Addition of anti-tubercular therapy to corticosteroids in uveitis patients with latent/manifest TB led to significant reduction in recurrences of uveitis.
Keyword Presumed intraocular tuberculosis
Immune deficiency syndrome
Choroidal tuberculoma
Mycobacterium tuberculosis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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