Ocular signs predictive of tubercular uveitis

Gupta, Amod, Bansal, Reema, Gupta, Vishali, Sharma, Aman and Bambery, Pradeep (2010) Ocular signs predictive of tubercular uveitis. American Journal of Ophthalmology, 149 4: 562-570. doi:10.1016/j.ajo.2009.11.020

Author Gupta, Amod
Bansal, Reema
Gupta, Vishali
Sharma, Aman
Bambery, Pradeep
Title Ocular signs predictive of tubercular uveitis
Journal name American Journal of Ophthalmology   Check publisher's open access policy
ISSN 0002-9394
Publication date 2010-04
Sub-type Article (original research)
DOI 10.1016/j.ajo.2009.11.020
Volume 149
Issue 4
Start page 562
End page 570
Total pages 9
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Abstract PURPOSE: To determine ocular signs predictive of tubercular uveitis. DESIGN: Retrospective, nonrandomized, comparative interventional case study. METHODS: Three hundred eighty-six patients with active uveitis were treated at a tertiary care single-center uveitis practice. Uveitis was presumed to be tubercular in patients who showed evidence of latent or manifest tuberculosis without any other known cause and who did not show recurrence of uveitis after 12 months of antitubercular therapy. One hundred eighty-two patients who thus obtained clinical diagnoses of presumed tubercular uveitis were enrolled in group A. Two hundred four patients with uveitis resulting from a nontubercular cause were enrolled in group B. Patients were monitored for the presence of types of keratic precipitates (mutton fat or fine), posterior synechiae (broad based or filiform), iris nodules, snowballs, snow banking, vasculitis (with or without choroiditis), serpiginous-like choroiditis, and other types of posterior uveitis (choroidal abscess, retinochoroiditis, or exudative retinal detachment) which were compared between the 2 groups. Statistical analysis was carried out at a 5% level of significance. The main outcome measures were clinical signs significantly associated with tubercular uveitis. RESULTS: Broad-based posterior synechiae, retinal vasculitis with or without choroiditis, and serpiginous-like choroiditis were seen significantly more commonly in patients with tubercular uveitis. Filiform posterior synechiae were more frequent in eyes with nontubercular uveitis. CONCLUSIONS: Broad-based posterior synechiae, retinal vasculitis with or without choroiditis, and serpiginous- like choroiditis in patients with latent or manifest tuberculosis in tuberculosis-endemic areas are suggestive of a tubercular cause of uveitis and merit specific treatment.
Keyword Intraocular tuberculosis
Clinical application
Choroidal tubercles
Retinal vasculitis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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