Improved periodontal health and cardiovascular risk

Rose-Hill, S., Ford, P. J., Leishman, S. J., Do, H. L., Palmer, J. E., Heng, N. C. K., West, M. J., Seymour, G. J. and Cullinan, M. P. (2011) Improved periodontal health and cardiovascular risk. Australian Dental Journal, 56 4: 352-357. doi:10.1111/j.1834-7819.2011.01363.x

Author Rose-Hill, S.
Ford, P. J.
Leishman, S. J.
Do, H. L.
Palmer, J. E.
Heng, N. C. K.
West, M. J.
Seymour, G. J.
Cullinan, M. P.
Title Improved periodontal health and cardiovascular risk
Journal name Australian Dental Journal   Check publisher's open access policy
ISSN 0045-0421
Publication date 2011-12
Sub-type Article (original research)
DOI 10.1111/j.1834-7819.2011.01363.x
Volume 56
Issue 4
Start page 352
End page 357
Total pages 6
Place of publication Oxford, England, U. K.
Publisher Wiley-Blackwell Publishing
Collection year 2012
Language eng
Formatted abstract
Background: Previous studies have demonstrated variable effects on systemic inflammatory and immune responses following improved periodontal health. This study examined changes in serum levels of the inflammatory mediators IL-1b,
IL-6, TNF-a and sICAM-1, and antibodies to Porphyromonas gingivalis, human heat shock protein (hHSP) 60 and P. gingivalis GroEL following improvement in periodontal health in high cardiovascular (CV) risk and low CV-risk patients.
Methods: Patients retrospectively selected from a longitudinal study, had undergone yearly periodontal examinations and peripheral blood collections. They had demonstrated a quantifiable improvement in periodontal health (>60% reduction in
number of sites with probing depth ‡4 mm from the baseline visit) and could be classified as either high CV-risk (‡6 classical risk factors, n = 13) or low CV-risk (£1 classical risk factor, n = 14). Serum levels of the cytokines and antibodies were
measured using ELISA.
Results: For sICAM-1 and anti-P. gingivalis GroEL and anti-hHSP60 antibodies, most patients recorded decreased levels.  Reductions in serum sICAM-1 levels were more notable in low CV-risk patients (p = 0.006); and reductions in levels of anti-
P. gingivalis GroEL and anti-hHSP60 antibodies (p = 0.001 and 0.009 respectively) were more notable in high CV-risk patients.
Conclusions: This study found that subsequent to improved periodontal health, the anti-HSP (HSP60 and GroEL) antibody response was reduced, particularly for high CV-risk patients. sICAM-1 levels were also lowered, more so for low CV-risk
Keyword Periodontal disease
Cardiovascular disease
Serum Antibodies
Porphyromonas gingivalis
Heat Shock Protein
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Accepted for publication 30 March 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Dentistry Publications
School of Medicine Publications
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