LPS-Induced Cytokine Production in Human Monocytes and Macrophages

Rosso, M., Heine, H., Meusch, U., Quandt, D., Klein, C., Sweet, M. J. and Hauschildt, S. (2011) LPS-Induced Cytokine Production in Human Monocytes and Macrophages. Critical Reviews in Immunology, 31 5: 379-446.

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Author Rosso, M.
Heine, H.
Meusch, U.
Quandt, D.
Klein, C.
Sweet, M. J.
Hauschildt, S.
Title LPS-Induced Cytokine Production in Human Monocytes and Macrophages
Journal name Critical Reviews in Immunology   Check publisher's open access policy
ISSN 1040-8401
Publication date 2011
Sub-type Article (original research)
Volume 31
Issue 5
Start page 379
End page 446
Total pages 68
Place of publication Redding, CT, United States
Publisher Begell House
Collection year 2012
Language eng
Formatted abstract
Lipopolysaccharide (LPS) from Gram-negative bacteria is one of the most potent innate immune-activating stimuli known. Here we review the current understanding of LPS effects on human monocyte and macrophage function. We provide an overview of LPS signal transduction with attention given to receptor cooperativity and species differences in LPS responses, as well as the role of tyrosine phosphorylation and lysine acetylation in signalling. We also review LPS-regulated transcription, with emphasis on chromatin remodeling and primary versus secondary transcriptional control mechanisms. Finally, we review the regulation and function of LPS-inducible cytokines produced by human monocytes and macrophages including TNFα, the IL-1 family, IL-6, IL-8, the IL-10 family, the IL-12 family, IL-15 and TGF
Keyword Monocytes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 140 times in Thomson Reuters Web of Science Article | Citations
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