Vasomotor menopausal symptoms are associated with increased risk of coronary heart disease

Gast, Gerrie-Cor M., Pop, Victor J. M., Samsioe, Goran N., Grobbee, Diederick E., Nilsson, Peter M., Keyzer, Jules J., Wijnands-van Gent, Colette J. M. and van der Schouw, Yvonne T. (2011) Vasomotor menopausal symptoms are associated with increased risk of coronary heart disease. Menopause, 18 2: 146-151. doi:10.1097/gme.0b013e3181f464fb

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Author Gast, Gerrie-Cor M.
Pop, Victor J. M.
Samsioe, Goran N.
Grobbee, Diederick E.
Nilsson, Peter M.
Keyzer, Jules J.
Wijnands-van Gent, Colette J. M.
van der Schouw, Yvonne T.
Title Vasomotor menopausal symptoms are associated with increased risk of coronary heart disease
Journal name Menopause   Check publisher's open access policy
ISSN 1072-3714
Publication date 2011-02
Sub-type Article (original research)
DOI 10.1097/gme.0b013e3181f464fb
Open Access Status
Volume 18
Issue 2
Start page 146
End page 151
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Collection year 2012
Language eng
Formatted abstract
Objective: Emerging evidence suggests that women with vasomotor menopausal symptoms (VMS) may have an adverse cardiovascular disease (CVD) risk profile. We investigated whether VMS are related to an increased risk of future coronary heart disease (CHD) and whether possible associations can be explained by CVD risk factors.
Methods: Data used were from a Dutch and Swedish population-based sample of 10,787 women enrolled between 1995 and 2000, aged 46 to 64 years, and free of CVD at baseline. Data on VMS were collected by questionnaires. Body mass index and blood pressure were measured in all women, and total cholesterol levels were measured in a subgroup of the population. Multivariable Cox regression models were used to analyze the data.
Results: After a mean ± SD follow-up period of 10.3 ± 2.1 years, 303 women were diagnosed with CHD. Symptoms of flushing were not associated with risk of CHD. However, the presence of night sweats was associated with a significantly modest increased risk of CHD, with a multivariable-adjusted hazard ratio of 1.33 (95% CI, 1.05-1.69). This association was attenuated but not eliminated after correction for body mass index, blood pressure, and total cholesterol (hazard ratio, 1.25; 95% CI, 0.99-1.58).
Conclusions: Women with menopausal symptoms of night sweats have a significantly moderately increased risk of CHD, which cannot be totally explained by the levels of CVD risk factors.
Keyword Vasomotor menopausal symptoms
Hot flushes
Night sweats
Coronary heart disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Public Health Publications
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Created: Thu, 12 Jan 2012, 13:44:19 EST by Gerrie-Cor Herber-Gast on behalf of School of Public Health