Synthesis of a new hyperbranched, vinyl macromonomer through the use of click chemistry: Synthesis and characterization of copolymer hydrogels with PEG diacrylate

Wang, David K., Hill, David J. T., Firas A. Rasoul and Andrew K. Whittaker (2012) Synthesis of a new hyperbranched, vinyl macromonomer through the use of click chemistry: Synthesis and characterization of copolymer hydrogels with PEG diacrylate. Journal of Polymer Science Part A: Polymer Chemistry, 50 6: 1143-1157. doi:10.1002/pola.25874


Author Wang, David K.
Hill, David J. T.
Firas A. Rasoul
Andrew K. Whittaker
Title Synthesis of a new hyperbranched, vinyl macromonomer through the use of click chemistry: Synthesis and characterization of copolymer hydrogels with PEG diacrylate
Journal name Journal of Polymer Science Part A: Polymer Chemistry   Check publisher's open access policy
ISSN 0887-624X
1099-0518
Publication date 2012-03
Year available 2011
Sub-type Article (original research)
DOI 10.1002/pola.25874
Volume 50
Issue 6
Start page 1143
End page 1157
Total pages 15
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2012
Language eng
Formatted abstract
A new biodegradable, water-soluble macromonomer based on the commercial hyperbranched polyester Boltorn®H20 has been synthesized through the use of click chemistry. The macromonomer was developed with the aim of being injected with a comacromonomer, poly(ethylene glycol) (PEG) diacrylate, for in situ copolymerization to form biodegradable polymer hydrogels. Copolymer hydrogels were prepared from the macromonomer and PEG diacrylate (FW 700) by free radical copolymerization. A degree of phase separation of the hydrogels was observed during polymerization and with increasing incorporation of the Boltorn macromonomer an increasing tendency for the formation of macropores was observed. The swelling ratios of the gels in water and phosphate buffered saline solution, PBS, all increase with increasing Boltorn macromonomer concentration, as did the penetrant diffusion coefficients and the degradation rate in PBS.
Keyword Biodegradable
Degradation
Hydrogels
Hyperbranched
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 21 DEC 2011.

 
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Created: Tue, 10 Jan 2012, 09:34:23 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging