Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease

Khor, Chiea Chuen, Davila, Sonia, Breunis, Willemijn B., Lee, Yi-Ching, Shimizu, Chisato, Wright, Victoria J., Yeung, Rae S. M., Tan, Dennis E. K., Sim, Kar Seng, Wang, Jie Jin, Wong, Tien Yin, Pang, Junxiong, Mitchell, Paul, Cimaz, Rolando, Dahdah, Nagib, Cheung, Yiu-Fai, Huang, Guo-Ying, Yang, Wanling L, Park, In-Sook, Lee, Jong-Keuk, Wu, Jer-Yuarn, Levin, Michael, Burns, Jane C., Burgner, David, Kuijpers, Taco W., Hibberd, Martin L., Lau, Yu-Lung, Zhang, Jing, Ma, Xiao-Jing, Liu, Fang, Wu, Lin, Yoo, Jeong Jin, Hong, Soo Jong, Kim, Kwi-Joo, Kim, Jae Jung, Park, Young Mi, Hong, Young-Mi, Sohn, Sejung, Jang, Gi Young, Ha, Kee Soo, Nam, Hyo-Kyoung, Byeon, Jung-Hye, Yun, Sin Weon, Han, Myung-Ki, Lee, Kyung-Yil, Hwang, Ja-Young, Rhim, Jung-Woo, Song, Min Seob, Lee, Hyoung-Doo, Kim, Dong-Soo, Lee, Jae-Moo, Chang, Jeng-Sheng, Tsai, Fuu-Jen, Liang, Chi-Di, Chen, Ming-Ren, Chi, Hsin, Chiu, Nan-Chang, Huang, Fu-Yuan, Chang, Luan Yin, Huang, Li Min, Kuo, Ho-Chang, Huang, Kao-Pin, Lee, Meng-Luen, Hwang, Betau, Huang, Yhu-Chering, Lee, Pi-Chang, Odam, Miranda, Christiansen, Frank T., Witt, Campbell, Goldwater, Paul, Curtis, Nigel, Palasanthiran, Pamela, Ziegler, John, Nissen, Michael, Nourse, Clare, Kuipers, Irene M., Ottenkamp, Jaap J., Geissler, Judy, Biezeveld, Maarten, Tacke, Carline, Filippini, Luke, Brogan, Paul, Klein, Nigel, Shah, Vanita, Dillon, Michael, Booy, Robert, Shingadia, Delane, Bose, Anu, Mukasa, Thomas, Tulloh, Robert, Michie, Colin, Newburger, Jane W., Baker, Annette L., Rowley, Anne H., Shulman, Standford T., Mason, Wilbert, Takahashi, Masato, Melish, Marian E., Tremoulet, Adriana H., Viswanathan, Ananth, Rochtchina, Elena, Attia, John, Scott, Rodney, Holliday, Elizabeth, Harrap, Stephen, Hong Kong-Shanghai Kawasaki Disease Genetics Consortium, Korean Kawasaki Disease Genetics Consortium, Taiwan Kawasaki Disease Genetics Consortium, International Kawasaki Disease Genetics Consortium, US Kawasaki Disease Genetics Consortium and Blue Mountain Eye Study (2011) Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nature Genetics, 43 12: 1241-1246. doi:10.1038/ng.981


Author Khor, Chiea Chuen
Davila, Sonia
Breunis, Willemijn B.
Lee, Yi-Ching
Shimizu, Chisato
Wright, Victoria J.
Yeung, Rae S. M.
Tan, Dennis E. K.
Sim, Kar Seng
Wang, Jie Jin
Wong, Tien Yin
Pang, Junxiong
Mitchell, Paul
Cimaz, Rolando
Dahdah, Nagib
Cheung, Yiu-Fai
Huang, Guo-Ying
Yang, Wanling L
Park, In-Sook
Lee, Jong-Keuk
Wu, Jer-Yuarn
Levin, Michael
Burns, Jane C.
Burgner, David
Kuijpers, Taco W.
Hibberd, Martin L.
Lau, Yu-Lung
Zhang, Jing
Ma, Xiao-Jing
Liu, Fang
Wu, Lin
Yoo, Jeong Jin
Hong, Soo Jong
Kim, Kwi-Joo
Kim, Jae Jung
Park, Young Mi
Hong, Young-Mi
Sohn, Sejung
Jang, Gi Young
Ha, Kee Soo
Nam, Hyo-Kyoung
Byeon, Jung-Hye
Yun, Sin Weon
Han, Myung-Ki
Lee, Kyung-Yil
Hwang, Ja-Young
Rhim, Jung-Woo
Song, Min Seob
Lee, Hyoung-Doo
Kim, Dong-Soo
Lee, Jae-Moo
Chang, Jeng-Sheng
Tsai, Fuu-Jen
Liang, Chi-Di
Chen, Ming-Ren
Chi, Hsin
Chiu, Nan-Chang
Huang, Fu-Yuan
Chang, Luan Yin
Huang, Li Min
Kuo, Ho-Chang
Huang, Kao-Pin
Lee, Meng-Luen
Hwang, Betau
Huang, Yhu-Chering
Lee, Pi-Chang
Odam, Miranda
Christiansen, Frank T.
Witt, Campbell
Goldwater, Paul
Curtis, Nigel
Palasanthiran, Pamela
Ziegler, John
Nissen, Michael
Nourse, Clare
Kuipers, Irene M.
Ottenkamp, Jaap J.
Geissler, Judy
Biezeveld, Maarten
Tacke, Carline
Filippini, Luke
Brogan, Paul
Klein, Nigel
Shah, Vanita
Dillon, Michael
Booy, Robert
Shingadia, Delane
Bose, Anu
Mukasa, Thomas
Tulloh, Robert
Michie, Colin
Newburger, Jane W.
Baker, Annette L.
Rowley, Anne H.
Shulman, Standford T.
Mason, Wilbert
Takahashi, Masato
Melish, Marian E.
Tremoulet, Adriana H.
Viswanathan, Ananth
Rochtchina, Elena
Attia, John
Scott, Rodney
Holliday, Elizabeth
Harrap, Stephen
Hong Kong-Shanghai Kawasaki Disease Genetics Consortium
Korean Kawasaki Disease Genetics Consortium
Taiwan Kawasaki Disease Genetics Consortium
International Kawasaki Disease Genetics Consortium
US Kawasaki Disease Genetics Consortium
Blue Mountain Eye Study
Title Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2011-12
Sub-type Article (original research)
DOI 10.1038/ng.981
Volume 43
Issue 12
Start page 1241
End page 1246
Total pages 6
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Collection year 2012
Language eng
Formatted abstract
Kawasaki disease is a systemic vasculitis of unknown etiology, with clinical observations suggesting a substantial genetic contribution to disease susceptibility. We conducted a genome-wide association study and replication analysis in 2,173 individuals with Kawasaki disease and 9,383 controls from five independent sample collections. Two loci exceeded the formal threshold for genome-wide significance. The first locus is a functional polymorphism in the IgG receptor gene FCGR2A (encoding an H131R substitution) (rs1801274; P = 7.35 × 10 -11, odds ratio (OR) = 1.32), with the A allele (coding for histadine) conferring elevated disease risk. The second locus is at 19q13, (P = 2.51 × 10 -9, OR = 1.42 for the rs2233152 SNP near MIA and RAB4B; P = 1.68 × 10 -12, OR = 1.52 for rs28493229 in ITPKC), which confirms previous findings. The involvement of the FCGR2A locus may have implications for understanding immune activation in Kawasaki disease pathogenesis and the mechanism of response to intravenous immunoglobulin, the only proven therapy for this disease.
Keyword Copy Number Variation
Intravenous Immunoglobulin
Ulcerative-Colitis
Population
Variants
Linkage
Polymorphism
Receptors
Children
Traits
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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