Th17 cells mediate clade-specific, serotype-independent mucosal immunity

Chen, Kong, McAleer, Jeremy P., Lin, Yuan, Paterson, David L., Xheng, Mingquan, Alcorn, John F., Weaver, Casey T. and Kolls, Jay K. (2011) Th17 cells mediate clade-specific, serotype-independent mucosal immunity. Immunity, 35 6: 997-1009. doi:10.1016/j.immuni.2011.10.018


Author Chen, Kong
McAleer, Jeremy P.
Lin, Yuan
Paterson, David L.
Xheng, Mingquan
Alcorn, John F.
Weaver, Casey T.
Kolls, Jay K.
Title Th17 cells mediate clade-specific, serotype-independent mucosal immunity
Journal name Immunity   Check publisher's open access policy
ISSN 1074-7613
1097-4180
Publication date 2011-12-23
Sub-type Article (original research)
DOI 10.1016/j.immuni.2011.10.018
Volume 35
Issue 6
Start page 997
End page 1009
Total pages 13
Place of publication Cambridge, MA, United States
Publisher Cell Press
Collection year 2012
Language eng
Abstract The interleukin-17 (IL-17) family of cytokines phylogenetically predates the evolution of T cells in jawed vertebrates, suggesting that the ontogeny of the Th17 cell lineage must have arisen to confer an evolutionary advantage to the host over innate sources of IL-17. Utilizing a model of mucosal immunization with the encapsulated bacteria Klebsiella pneumoniae, we found that B cells, which largely recognized polysaccharide capsular antigens, afforded protection to only the vaccine strain. In contrast, memory Th17 cells proliferated in response to conserved outer membrane proteins and conferred protection against several serotypes of K. pneumoniae, including the recently described multidrug resistant New Dehli metallolactamase strain. Notably, this heterologous, clade-specific protection was antibody independent, demonstrating the Th17 cell lineage confers a host advantage by providing heterologous mucosal immunity independent of serotype-specific antibody.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2012 Collection
School of Medicine Publications
 
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Created: Thu, 05 Jan 2012, 11:49:03 EST by Laurie Beechey on behalf of UQ Centre for Clinical Research