Prognostic factors for survival of stage IB upper lobe non-small cell lung cancer patients: A retrospective study in Shanghai, China

Wang, Wen-li, Yang Shen-tu and Wang, Zhi-qiang (2011) Prognostic factors for survival of stage IB upper lobe non-small cell lung cancer patients: A retrospective study in Shanghai, China. Chinese Journal of Cancer Research, 23 4: 265-270. doi:10.1007/s11670-011-0265-2

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Author Wang, Wen-li
Yang Shen-tu
Wang, Zhi-qiang
Title Prognostic factors for survival of stage IB upper lobe non-small cell lung cancer patients: A retrospective study in Shanghai, China
Journal name Chinese Journal of Cancer Research   Check publisher's open access policy
ISSN 1000-9604
1993-0631
Publication date 2011-12
Sub-type Article (original research)
DOI 10.1007/s11670-011-0265-2
Volume 23
Issue 4
Start page 265
End page 270
Total pages 6
Place of publication Beijing, China
Publisher China Anti-Cancer Association
Collection year 2012
Language eng
Formatted abstract
Objective: To identify clinical and pathologic factors that were associated with the survival of stage IB upper lobe non-small cell lung cancer (NSCLC) patients.
Methods: A retrospective study of 147 subjects who had undergone curative resection for stage IB upper lobe NSCLC was performed. Patients who had received any adjuvant or neo-adjuvant chemotherapy were excluded. Survival function curves were estimated using the Kaplan-Meier procedure. Crude and adjusted hazard ratios (HRs) of potential prognostic factors were estimated using Cox proportional hazards models.
Results: Five factors, including age, tumor size, histologic grade of differentiation, number of removed superior mediastinal lymph node stations and presence of visceral pleura invasion, were significantly and independently associated with mortality risk. Adjusted HRs were 2.6 [95% confidence interval (95% CI): 1.1–6.5] and 4.6 (95% CI: 1.9–11) for those aged 58–68 years and those >68 years, respectively, relative to those aged <58 years. HRs for those with poorly and moderately differentiated tumors were 6.4 (95% CI: 2.3–18) and 1.4 (95% CI: 0.7–2.8), respectively. HRs for those with tumor size 3.1–5 cm and >5 cm (vs ≤3.0 cm) were 2.3 (95% CI: 1.1–4.9) and 4.3 (95% CI: 1.9–10), respectively. The presence of visceral pleura invasion also increased the risk of mortality (HR=4.0, 95% CI: 1.3–12).
Conclusion: Advanced age, larger tumor size, poorly differentiated histology, smaller number of removed superior mediastinal lymph node stations, and presence of visceral pleura invasion were associated with poor survival of surgically treated stage IB upper lobe NSCLC patients.
Keyword Non-small cell lung cancer
Stage IB
Prognosis
Lymphadenectomy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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Created: Thu, 05 Jan 2012, 09:37:21 EST by Zhiqiang Wang on behalf of Medicine - Royal Brisbane and Women's Hospital