Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2'-amino-LNA monomers

Pasternak, Karol, Pasternak, Anna, Gupta, Pankaj, Veedu, Rakesh N. and Wengel, Jesper (2011) Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2'-amino-LNA monomers. Bioorganic and Medicinal Chemistry, 19 24: 7407-7415. doi:10.1016/j.bmc.2011.10.052


Author Pasternak, Karol
Pasternak, Anna
Gupta, Pankaj
Veedu, Rakesh N.
Wengel, Jesper
Title Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2'-amino-LNA monomers
Formatted title
Photoligation of self-assembled DNA constructs containing anthracene-functionalized 2′-amino-LNA monomers
Journal name Bioorganic and Medicinal Chemistry   Check publisher's open access policy
ISSN 0968-0896
1464-3391
Publication date 2011-12-15
Sub-type Article (original research)
DOI 10.1016/j.bmc.2011.10.052
Volume 19
Issue 24
Start page 7407
End page 7415
Total pages 9
Editor K. D. Janda
Place of publication Oxford, United Kingdom
Publisher Pergamon
Collection year 2012
Language eng
Formatted abstract
Efficient synthesis of a novel anthracene-functionalized 2′-amino-LNA phosphoramidite derivative is described together with its incorporation into oligodeoxynucleotides. Two DNA strands with the novel 2′-N-anthracenylmethyl-2′-amino-LNA monomers can be effectively cross-linked by photoligation at 366 nm in various types of DNA constructs. Successful application of three differently functionalized 2′-amino-LNA monomers in self-assembled higher ordered structures for simultaneous cross-linking and monitoring of assembly formation is furthermore demonstrated.
Keyword Amino-LNA
Anthracene
Photoligation
DNA cross-linking
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 20 October 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Wed, 04 Jan 2012, 08:43:52 EST by Lucy O'Brien on behalf of School of Chemistry & Molecular Biosciences