Manufactured RBC - Rivers of blood, or an oasis in the desert?

Timmins, N. E. and Nielsen, L. K. (2011) Manufactured RBC - Rivers of blood, or an oasis in the desert?. Biotechnology Advances, 29 6: 661-666. doi:10.1016/j.biotechadv.2011.05.002


Author Timmins, N. E.
Nielsen, L. K.
Title Manufactured RBC - Rivers of blood, or an oasis in the desert?
Journal name Biotechnology Advances   Check publisher's open access policy
ISSN 0734-9750
1873-1899
Publication date 2011-11
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.biotechadv.2011.05.002
Volume 29
Issue 6
Start page 661
End page 666
Total pages 6
Place of publication New York, NY, United States
Publisher Elsevier
Collection year 2012
Language eng
Abstract Red blood cell (RBC) transfusion is an essential practice in modern medicine, one that is entirely dependent on the availability of donor blood. Constraints in donor supply have led to proposals that transfusible RBC could be manufactured from stem cells. While it is possible to generate small amounts of RBC in vitro, very large numbers of cells are required to be of clinical significance. We explore the challenges facing large scale manufacture of RBC and technological developments required for such a scenario to be realised.
Keyword Red blood cells
Erythropoiesis
Blood transfusion
Cell therapy
Bioreactors
Cell culture
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 14 May 2011

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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