Hyperplastic polyp of the duodenum: a report of 9 cases with immunohistochemical and molecular findings

Rosty, Christophe, Buchanan, Daniel D., Walters, Rhiannon J., Carr, Norman J., Bothman, John W., Young, Joanne P. and Brown, Ian S. (2011) Hyperplastic polyp of the duodenum: a report of 9 cases with immunohistochemical and molecular findings. Human Pathology, 42 12: 1953-1959. doi:10.1016/j.humpath.2011.02.018


Author Rosty, Christophe
Buchanan, Daniel D.
Walters, Rhiannon J.
Carr, Norman J.
Bothman, John W.
Young, Joanne P.
Brown, Ian S.
Title Hyperplastic polyp of the duodenum: a report of 9 cases with immunohistochemical and molecular findings
Journal name Human Pathology   Check publisher's open access policy
ISSN 0046-8177
1532-8392
Publication date 2011-12
Sub-type Article (original research)
DOI 10.1016/j.humpath.2011.02.018
Volume 42
Issue 12
Start page 1953
End page 1959
Total pages 7
Place of publication Maryland Heights, MO, United States
Publisher W.B. Saunders
Collection year 2012
Language eng
Formatted abstract
Benign serrated polyps are commonly found in the colorectum but have rarely been described in other parts of the gastrointestinal tract. We report a series of 9 serrated polyps arising in the duodenum with clinicopathologic features, immunohistochemical expression profile of mucins (MUC2, MUC5AC, MUC6), and molecular analysis for BRAF and KRAS. The polyps were diagnosed as incidental endoscopy findings in 9 different patients, comprising 3 male and 6 female patients, with a mean age of 52.2 years (range, 21-72 years). The second part of the duodenum was the most common site (n = 5), followed by the ampulla (n = 1) and the distal duodenum (n = 1), with the location of the 2 remaining polyps unspecified. Other upper gastrointestinal tract pathology features included Barrett esophagus for 5 patients, Helicobacter gastritis for 1 patient, and mild chronic gastritis for 1 patient. The histologic appearance of the polyps was similar to microvesicular hyperplastic polyp in the colorectum. Immunostaining for mucins showed MUC6 expression in the crypt bases of all polyps, MUC5AC expression in 8 cases (89%), and mucin 2 expression in 6 cases (67%). Molecular testing was successful in 6 polyps, showing BRAF mutation (V600E) in 2 polyps, KRAS mutation in 2 polyps, and no mutation for either gene in 2 polyps. Colonoscopy reports were available for 6 patients, of whom 4 were diagnosed with hyperplastic polyps or sessile serrated polyps in the colorectum. However, no patient met the criteria for serrated polyposis. Although probably rare and of uncertain malignant potential, hyperplastic polyp should be considered in the differential diagnosis of benign duodenal polyp.
Keyword Hyperplastic polyp
Duodenum
Mucins
BRAF
KRAS
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
 
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