Bisphosphonate treatment delays stress fracture remodeling in the rat ulna

Kidd, L. J., Cowling, N. R., Wu, A. C. K., Kelly, W. L. and Forwood, M. R. (2011) Bisphosphonate treatment delays stress fracture remodeling in the rat ulna. Journal of Orthopaedic Research, 29 12: 1827-1833.


Author Kidd, L. J.
Cowling, N. R.
Wu, A. C. K.
Kelly, W. L.
Forwood, M. R.
Title Bisphosphonate treatment delays stress fracture remodeling in the rat ulna
Journal name Journal of Orthopaedic Research  (ERA 2012 Listed)    (ERA 2010 Rank A*)   Check publisher's open access policy
Publication date 2011-12
Sub-type Article
DOI 10.1002/jor.21464
Volume number 29
Issue number 12
ISSN 0736-0266; 1554-527X
Start page 1827
End page 1833
Total pages 7
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Collection year 2012
Language eng
Abstract Because bisphosphonates (BPs) are potent inhibitors of bone resorption, we hypothesized that they would retard direct remodeling of stress fractures. The aim of this study was to determine the effect of risedronate on direct remodeling and woven bone callus formation following stress fracture formation in the rat ulna. In 135 adult female Wistar rats, cyclic loading of the ulna created stress fractures. Rats were treated daily with oral saline, or risedronate at 0.1 or 1.0 mg/kg. From each bone, histomorphometry was performed on sections stained with toluidine blue at a standard level along the fracture. The high dose of risedronate caused a significant decrease in the percentage of repaired stress fracture and bone resorption along the stress fracture line at 6 and 10 weeks after loading (p < 0.05). At this dose, intracortical resorption was significantly reduced at 10 weeks after loading and intracortical new bone area was significantly reduced at 6 and 10 weeks. Woven bone formation and consolidation phases of stress fracture repair were not affected by low or high doses of risedronate. In conclusion, high dose bisphosphonate treatment impaired healing of a large stress fracture line by reducing the volume of bone resorbed and replaced during remodeling. We also confirmed that periosteal callus formation was not adversely affected by risedronate treatment.
Keyword Stress fracture
Bone remodeling
Bisphosphonate
Risedronate
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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