Sperm surface changes and physiological consequences induced by sperm handling and storage

Leahy, Tamara and Gadella, Bart M. (2011) Sperm surface changes and physiological consequences induced by sperm handling and storage. Reproduction, 142 6: 759-778. doi:10.1530/REP-11-0310


Author Leahy, Tamara
Gadella, Bart M.
Title Sperm surface changes and physiological consequences induced by sperm handling and storage
Journal name Reproduction   Check publisher's open access policy
ISSN 1470-1626
1741-7899
Publication date 2011-12
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1530/REP-11-0310
Volume 142
Issue 6
Start page 759
End page 778
Total pages 20
Place of publication Bristol, United Kingdom
Publisher BioScientifica
Collection year 2012
Language eng
Abstract Spermatozoa interact with their immediate environment and this contact remodels the sperm surface in preparation for fertilisation. These fundamental membrane changes will be critically covered in this review with special emphasis on the very specific surface destabilisation event, capacitation. This process involves very subtle and intricate modifications of the sperm membrane including removal of suppression (decapacitation) factors and changes in the lateral organisation of the proteins and lipids of the sperm surface. Processing of sperm for assisted reproduction (storage, sex-sorting, etc.) subjects spermatozoa to numerous stressors, and it is possible that this processing overrides such delicate processes resulting in sperm instability and cell damage. To improve sperm quality, novel mechanisms must be used to stabilise the sperm surface during handling. In this review, different types of membrane stress are considered, as well as novel surface manipulation methods to improve sperm stability.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
School of Veterinary Science Publications
 
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