Blue-black rule: A simple dermoscopic clue to recognize pigmented nodular melanoma

Argenziano, G., Longo, C., Cameron, A., Cavicchini, S., Gourhant, J. Y., Lallas, A., McColl, I., Rosendahl, C., Thomas, L., Tiodorovic-Zivkovic, D., Zaballos, P. and Zalaudek, I. (2011) Blue-black rule: A simple dermoscopic clue to recognize pigmented nodular melanoma. British Journal of Dermatology, 165 6: 1251-1255. doi:10.1111/j.1365-2133.2011.10621.x

Author Argenziano, G.
Longo, C.
Cameron, A.
Cavicchini, S.
Gourhant, J. Y.
Lallas, A.
McColl, I.
Rosendahl, C.
Thomas, L.
Tiodorovic-Zivkovic, D.
Zaballos, P.
Zalaudek, I.
Title Blue-black rule: A simple dermoscopic clue to recognize pigmented nodular melanoma
Journal name British Journal of Dermatology   Check publisher's open access policy
ISSN 0007-0963
Publication date 2011-12
Sub-type Article (original research)
DOI 10.1111/j.1365-2133.2011.10621.x
Volume 165
Issue 6
Start page 1251
End page 1255
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2012
Language eng
Formatted abstract
Background Dermoscopy improves melanoma recognition, but most criteria were described in the context of superficial spreading melanoma. Objectives To test whether pigmented nodular melanoma could be recognized dermoscopically by the presence of a combination of blue and black colour within the lesion. Methods Dermoscopic images of histopathologically diagnosed pigmented nodular tumours with no (or only minimal) flat component were evaluated for the presence of standard melanoma criteria and for the presence of a new feature named blue-black (BB) colour. Sensitivity, specificity, positive predictive value and negative predictive value were calculated for standard criteria and BB feature in relation to the diagnosis of melanoma and to diagnosis of malignancy. Results Of 283 lesions, 160 were malignant, including 78 (27Æ6%) melanomas, and 123 were benign. The BB feature and the standard criteria had 78Æ2% and 43Æ6% sensitivity for melanoma, respectively, whereas a combined method based on the presence of either the BB feature or one (or more) of the standard criteria reached 84Æ6% sensitivity, with 80Æ5% specificity and 93Æ2% negative predictive value. Sensitivity values for malignant lesions were only 24Æ4%, 56Æ9% and 60% for standard criteria, BB feature and the combined method, respectively. However, the combined method gave 91Æ9% specificity and 90Æ6% positive predictive value for malignancy. Conclusions Using a method based on the BB feature or one of the standard melanoma criteria, only 9Æ4% of positive pigmented nodular lesions were found to be benign and only 6Æ8% of negative lesions were found to be melanoma histopathologically.
Keyword Skin Lesions
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
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