Do we understand the impact of altered physiology, consequent interventions and resultant clinical scenarios in the intensive care unit? The antibiotic story

Lipman, J., Udy, A. and Roberts, Jason (2011) Do we understand the impact of altered physiology, consequent interventions and resultant clinical scenarios in the intensive care unit? The antibiotic story. Anaesthesia and Intensive Care, 39 6: 999-1000.

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Name Description MIMEType Size Downloads
Author Lipman, J.
Udy, A.
Roberts, Jason
Title Do we understand the impact of altered physiology, consequent interventions and resultant clinical scenarios in the intensive care unit? The antibiotic story
Journal name Anaesthesia and Intensive Care   Check publisher's open access policy
ISSN 0310-057X
1448-0271
Publication date 2011-11
Sub-type Editorial
Volume 39
Issue 6
Start page 999
End page 1000
Total pages 2
Place of publication Edgecliff, NSW, Australia
Publisher Australian Society of Anaesthetists
Collection year 2012
Language eng
Abstract Early, appropriate antibacterial therapy is a key factor in effectively managing septic critically ill patients1. The prescriber must not only employ an agent of appropriate spectrum, but also in an adequate dose to achieve bacterial eradication at the site of infection. However, the relationship between drug administration and therapeutic success is complex in the critically ill, such that a patient’s physiology heavily influences the way drugs distribute into tissue and are eliminated. This represents a significant challenge to the emergency or intensive care physician, and in this manner, personalising therapy, through a greater understanding of how a drug will behave in an individual patient, is likely to lead to improved outcomes. [Extract from editorial]
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes "Editorials"

Document type: Journal Article
Sub-type: Editorial
Collections: Temporary Review
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 22 Dec 2011, 15:52:18 EST by Sia Athanasas on behalf of Anaesthesiology and Critical Care - RBWH