Respiratory syncytial virus infection and immunoprophylaxis for selected high-risk children in Central Australia

Bolisetty, Srinivas, Wheaton, Gavin and Chang, Anne B. (2005) Respiratory syncytial virus infection and immunoprophylaxis for selected high-risk children in Central Australia. Australian Journal of Rural Health, 13 5: 265-270. doi:10.1111/j.1440-1584.2005.00715.x


Author Bolisetty, Srinivas
Wheaton, Gavin
Chang, Anne B.
Title Respiratory syncytial virus infection and immunoprophylaxis for selected high-risk children in Central Australia
Journal name Australian Journal of Rural Health   Check publisher's open access policy
ISSN 1038-5282
1440-1584
Publication date 2005-10-01
Sub-type Article (original research)
DOI 10.1111/j.1440-1584.2005.00715.x
Volume 13
Issue 5
Start page 265
End page 270
Total pages 6
Place of publication Richmond, Vic., Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Formatted abstract
Background: There are limited data on the epidemiology and viral aetiology of bronchiolitis in Central Australia and respiratory syncytial virus (RSV) immunoprophylaxis in an Australian population.
Objective: To (i) determine the incidence and the viral aetiology of bronchiolitis hospitalisations and (ii) report on the usage of RSV immunoprophylaxis in selected high-risk infants and children in Central Australia.
Methodology: A retrospective review was performed of all hospital separations for bronchiolitis for a three-year period, 1998–2000. Respiratory viruses in the nasopharyngeal aspirates were identified from the cases in the year 2000. A combined retrospective chart review and prospective follow up study was undertaken of all the infants and children who received RSV immunoprophylaxis at the Alice Springs Hospital, Central Australia.
Results: Incidence of bronchiolitis hospitalisation in infants for 1998, 1999 and 2000 were 176, 200 and 180 per 1000, respectively. Nine high-risk children had RSV immunoprophylaxis on a total of 46 occasions and there were two mild RSV-related illnesses in them. None had severe lower respiratory tract illness.
Conclusion: The incidence of bronchiolitis in Central Australia is extremely high. The usage of RSV immunoprophylaxis may be justified in selected high-risk children living in high endemic areas.
Keyword Bronchiolitis
Central Australia
Palivizumab
RSV-IGIV
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Tue, 20 Dec 2011, 00:45:35 EST by Jane Medhurst on behalf of Child Health Research Centre