Calcitonin gene-related peptide relates to cough sensitivity in children with chronic cough

Chang, A. B., Gibson, P. G., Ardill, J. E. and McGarvey, L. P. A. (2007) Calcitonin gene-related peptide relates to cough sensitivity in children with chronic cough. European Respiratory Journal, 30 1: 66-72. doi:10.1183/09031936.00150006

Author Chang, A. B.
Gibson, P. G.
Ardill, J. E.
McGarvey, L. P. A.
Title Calcitonin gene-related peptide relates to cough sensitivity in children with chronic cough
Journal name European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
Publication date 2007-07-01
Sub-type Article (original research)
DOI 10.1183/09031936.00150006
Volume 30
Issue 1
Start page 66
End page 72
Total pages 7
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Language eng
Formatted abstract
Airway neuropeptides, in particular calcitonin gene-related peptide (CGRP), are likely to be important in the pathogenesis of chronic cough. The present authors evaluated the following: 1) the relationship between cough sensitivity and bronchoalveolar lavage (BAL) neuropeptides; and 2) the effect of reflux oesophagitis (RO) on cough, cough sensitivity and BAL neuropeptides in children not selected for cough. It was hypothesised that CGRP would be increased in children with chronic cough and would relate to cough sensitivity.

Capsaicin cough sensitivity was performed in children undergoing gastro-duodenal endoscopy. CGRP, substance P and neurokinin A were measured in BAL obtained nonbronchoscopically. Children were defined as “coughers” if chronic cough was present.

Coughers (nā€Š=ā€Š21) had significantly reduced cough sensitivity but were just as likely as noncoughers (nā€Š=ā€Š19) to have RO. The median CGRP was significantly higher in coughers with oesophagitis than in noncoughers with oesophagitis. CGRP significantly negatively correlated to cough sensitivity in coughers but not in noncoughers.

Elevated calcitonin gene-related peptide, but not substance P or neurokinin A, is only associated with chronic cough in children when oesophagitis coexists. Calcitonin gene-related peptide in bronchoalveolar lavage relates to cough sensitivity and is likely to be important in the pathophysiology of chronic cough.
Keyword Calcitonin gene-related peptide
Capsaicin cough sensitivity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Mon, 19 Dec 2011, 14:28:08 EST by Jane Medhurst on behalf of Child Health Research Centre