The burden of disease in non-cystic fibrosis bronchiectasis

Kapur, Nitin, Masters, I. Brent, Newcombe, Peter and Chang, Anne B. (2012) The burden of disease in non-cystic fibrosis bronchiectasis. Chest, 141 4: 1018-1024. doi:10.1378/chest.11-0679

Author Kapur, Nitin
Masters, I. Brent
Newcombe, Peter
Chang, Anne B.
Title The burden of disease in non-cystic fibrosis bronchiectasis
Journal name Chest   Check publisher's open access policy
ISSN 0012-3692
Publication date 2012-04
Year available 2011
Sub-type Article (original research)
DOI 10.1378/chest.11-0679
Open Access Status
Volume 141
Issue 4
Start page 1018
End page 1024
Total pages 6
Place of publication Northbrook, IL, United States
Publisher American College of Chest Physicians
Collection year 2012
Language eng
Formatted abstract
The burden of disease in children with non-cystic fibrosis (CF) bronchiectasis is unknown. Our study aimed to identify the determinants of quality of life (QOL) and parental mental health in this group of patients and their parents; and to evaluate the effect of exacerbations on these parameters.


Parents of 69 children (median age 7 years) with non-CF bronchiectasis prospectively completed two questionnaires [parent-proxy cough-specific QOL (PC-QOL) and Depression, Anxiety and Stress scale (DASS)] at stable and exacerbation states. Data on clinical, investigational and lung function parameters were also collected.

During stable-state, the median [Inter-quartile range (IQR)] PC-QOL was 6.5 (5.3-6.9) and DASS-21 was 6 (0-20). Young age of children correlated with worse QOL (rs=0.242, p=0.04) but radiological extent, lung function, underlying etiology, environmental tobacco smoke exposure and chronic upper-airway disease did not influence these scores. Exacerbations caused significant worsening in PC-QOL [median (IQR) 4.6 (3.8-5.4); p=<0.001] and DASS scores [22 (9-42); p<0.001; 38% with elevated anxiety 54% abnormal depression/stress scores during exacerbation]. Presence of viral infection, hypoxia and hospitalization did not influence exacerbation PC-QOL and DASS scores.


There is a significant burden of disease, especially during exacerbation, on parents of children with bronchiectasis. Prevention, early detection and appropriate management of exacerbations are likely to reduce psychological morbidity in this group.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 1 September 2011.

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Created: Mon, 19 Dec 2011, 13:24:57 EST by Jane Medhurst on behalf of Child Health Research Centre