Background: The burden of disease in children with non-cystic fibrosis (CF) bronchiectasis is unknown. Our study aimed to identify the determinants of quality of life (QOL) and parental mental health in this group of patients and their parents; and to evaluate the effect of exacerbations on these parameters. Methods: Parents of 69 children (median age 7 years) with non-CF bronchiectasis prospectively completed two questionnaires [parent-proxy cough-specific QOL (PC-QOL) and Depression, Anxiety and Stress scale (DASS)] at stable and exacerbation states. Data on clinical, investigational and lung function parameters were also collected. Results: During stable-state, the median [Inter-quartile range (IQR)] PC-QOL was 6.5 (5.3-6.9) and DASS-21 was 6 (0-20). Young age of children correlated with worse QOL (rs=0.242, p=0.04) but radiological extent, lung function, underlying etiology, environmental tobacco smoke exposure and chronic upper-airway disease did not influence these scores. Exacerbations caused significant worsening in PC-QOL [median (IQR) 4.6 (3.8-5.4); p=<0.001] and DASS scores [22 (9-42); p<0.001; 38% with elevated anxiety 54% abnormal depression/stress scores during exacerbation]. Presence of viral infection, hypoxia and hospitalization did not influence exacerbation PC-QOL and DASS scores. Conclusions: There is a significant burden of disease, especially during exacerbation, on parents of children with bronchiectasis. Prevention, early detection and appropriate management of exacerbations are likely to reduce psychological morbidity in this group.