IL-6 and TNF alpha across the umbilical circulation in term pregnancies: Relationship with labour events

Duncombe, Greg, Veldhuizen, Ruud A.W., Gratton, Robert J., Han, Victor K.M. and Richardson, Bryan S. (2010) IL-6 and TNF alpha across the umbilical circulation in term pregnancies: Relationship with labour events. Early Human Development, 86 2: 113-117. doi:10.1016/j.earlhumdev.2010.01.027


Author Duncombe, Greg
Veldhuizen, Ruud A.W.
Gratton, Robert J.
Han, Victor K.M.
Richardson, Bryan S.
Title IL-6 and TNF alpha across the umbilical circulation in term pregnancies: Relationship with labour events
Formatted title
IL-6 and TNFα across the umbilical circulation in term pregnancies: Relationship with labour events
Journal name Early Human Development   Check publisher's open access policy
ISSN 0378-3782
1872-6232
Publication date 2010-02
Sub-type Article (original research)
DOI 10.1016/j.earlhumdev.2010.01.027
Volume 86
Issue 2
Start page 113
End page 117
Total pages 5
Place of publication Shannon, Ireland
Publisher Elsevier Ireland
Language eng
Formatted abstract
Objective: We have determined venous and arterial cord blood levels for IL-6 and TNFα at the time of delivery to assess gestational tissue versus fetal sources in labouring and non-labouring patients at term, and the relationship to labour events.
Methods: Fifty-five patients were studied (elective cesarean section n=24, and labouring n=31) with blood sampling from a clamped segment of cord after delivery of the fetus and from the cord at its insertion into the placenta after delivery of the placenta, with subsequent measurement of blood gases, pH, IL-6 and TNFα.
Results: Umbilical cord levels for IL-6 were increased by 4 fold in low risk labouring patients, and a further 6 fold when showing histologic chorioamnionitis, but with no evident effect of nuchal cord with ‘variable’ fetal heart rate decelerations, fetal acidemia, nor of labour duration. IL-6 levels from the cord at its insertion into the placenta were generally higher than those from the respective umbilical levels indicating that placental release of IL-6 into cord blood must be occurring. However, a consistent venoarterial difference for IL-6 and thereby a net flux from the placenta could not be demonstrated. TNFα levels for both patient groups were uniformly low for all of the cord measurements with no significant differences noted.
Conclusion: Umbilical cord levels for IL-6 are increased in low risk labouring patients at term in the absence of evident infection which likely involves both gestational tissue and fetal contributions. Cord levels for IL-6 are further increased in low risk labouring patients showing histologic chorioamnionitis which might then contribute to newborn morbidity in these pregnancies.
Keyword Il-6
TNF alpha
Umbilical circulation
Term labour
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
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