Synthesis of the Thiazole-Thiazoline Fragment of Largazole Analogues

Diness, Frederik, Nielsen, Daniel S. and Fairlie, David P. (2011) Synthesis of the Thiazole-Thiazoline Fragment of Largazole Analogues. Journal of Organic Chemistry, 76 23: 9845-9851. doi:10.1021/jo201675r


Author Diness, Frederik
Nielsen, Daniel S.
Fairlie, David P.
Title Synthesis of the Thiazole-Thiazoline Fragment of Largazole Analogues
Journal name Journal of Organic Chemistry   Check publisher's open access policy
ISSN 0022-3263
1520-6904
Publication date 2011-12
Sub-type Article (original research)
DOI 10.1021/jo201675r
Volume 76
Issue 23
Start page 9845
End page 9851
Total pages 7
Place of publication Washington, DC, United States
Publisher American Chemical Society
Collection year 2012
Language eng
Formatted abstract
The thiazole - thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole - oxazoline, and other thiazole - thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties
Keyword Histone Deacetylase Inhibitor
Elongation-Factor-Tu
Natural-Products
Thiopeptide Antibiotics
Biological-Activity
Structural Basis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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