MicroRNAs in β-cell biology, insulin resistance, diabetes and its complications

Fernandez Valverde, Selene L., Taft, Ryan J. and Mattick, John S. (2011) MicroRNAs in β-cell biology, insulin resistance, diabetes and its complications. Diabetes, 60 7: 1825-1831. doi:10.2337/db11-0171

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Author Fernandez Valverde, Selene L.
Taft, Ryan J.
Mattick, John S.
Title MicroRNAs in β-cell biology, insulin resistance, diabetes and its complications
Journal name Diabetes   Check publisher's open access policy
ISSN 0012-1797
Publication date 2011-07
Sub-type Article (original research)
DOI 10.2337/db11-0171
Volume 60
Issue 7
Start page 1825
End page 1831
Total pages 7
Place of publication Alexandria, VA, United States
Publisher American Diabetes Association
Collection year 2012
Language eng
Abstract MicroRNAs (miRNAs) are small 19-23 nucleotide RNA molecules that act as regulators of protein expression in eukaryotic cells by inducing the translations] arrest and degradation of messenger RNAs (1). They are potent drivers of differentiation and development (1), and their dysregulation has been linked to many diseases. Here, we present an overview of the known and proposed roles and effects of miRNAs in type 1 and type 2 diabetes (TlD and T2D), focusing on β-cell biology, insulin resistance, and diabetes complications. Specifically, we discuss miRNAs in β-cell biology, altered expression of miRNAs in adipose tissue in response to obesity, and miRNA dysfunction in organs and tissues that may be affected in later stages of the disease. Additionally, we propose a set of research directions that may yield novel diagnostic and therapeutic approaches for this chronic illness. [First paragraph - No abstract available]
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 79 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 16 Dec 2011, 11:27:05 EST by Susan Allen on behalf of Institute for Molecular Bioscience