Tracking of leptin, soluble leptin receptor, and the free leptin index during weight loss and regain in children

Holm, Jens-Christian, Gamborg, Michael, Ward, Leigh C., Gammeltoft, Steen, Kaas-Ibsen, Karsten, Heitmann, Berit L. and Sørensen, Thorkild I.A. (2011) Tracking of leptin, soluble leptin receptor, and the free leptin index during weight loss and regain in children. Obesity Facts, 4 6: 461-468. doi:10.1159/000335121

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Author Holm, Jens-Christian
Gamborg, Michael
Ward, Leigh C.
Gammeltoft, Steen
Kaas-Ibsen, Karsten
Heitmann, Berit L.
Sørensen, Thorkild I.A.
Title Tracking of leptin, soluble leptin receptor, and the free leptin index during weight loss and regain in children
Journal name Obesity Facts   Check publisher's open access policy
ISSN 1662-4025
Publication date 2011
Year available 2011
Sub-type Article (original research)
DOI 10.1159/000335121
Open Access Status DOI
Volume 4
Issue 6
Start page 461
End page 468
Total pages 8
Editor L. Hebebrand
Place of publication Basel, Switzerland
Publisher Karger
Collection year 2012
Language eng
Formatted abstract
To investigate changes in leptin and soluble leptin receptor (SLR) concentrations, and in the free leptin index (FLI) during weight loss and subsequent weight regain; and to ascertain whether these indices remain stable in the rank of the distribution in repeated measures (tracking) during perturbations of weight in obese children.

Design and Measurements:
In a longitudinal study, 115 obese children were examined during a 12-week weight loss programme and 28 months of follow-up. Height, weight, body composition, Tanner stages, testicular size, time of menarche, and concentrations of leptin and SLR were measured at baseline, on days 14, 33, and 82, and from months 10, 16, and 28.

During weight loss, leptin decreased and the SLR increased. During weight regain, leptin increased and the SLR decreased. The partial correlation coefficients expressing the relationship between leptin and SLR were significant in girls during both weight loss and weight regain, whereas in boys they were much weaker and not significant. Leptin, SLR and FLI exhibited individual-specific levels (tracking) during weight loss and regain in boys
and girls. The observed tracking seemed stronger during weight loss than during weight regain. The observed tracking was independent of both baseline body mass index (BMI) standard deviation score (SDS) and pubertal development at baseline and of subsequent changes in BMI SDS and puberty stages.

Leptin and the SLR exhibit tracking during weight loss and regain, which indicates individual stability in the leptin system despite challenges of weight.
Keyword Child
Free leptin index
Longitudinal study
Soluble leptin receptor
Weight loss
Weight regain
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: December 6, 2011

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 13 Dec 2011, 08:31:21 EST by Lucy O'Brien on behalf of School of Chemistry & Molecular Biosciences