Effects of vitamin D supplementation on cognitive and emotional functioning in young adults: a randomised controlled trial

Dean, Angela J., Bellgrove, Mark, Hall, Teresa, Phan, Wei Ming Jonathan, Eyles, Darryl, Kvaskoff, David and McGrath, John J. (2011) Effects of vitamin D supplementation on cognitive and emotional functioning in young adults: a randomised controlled trial. PLoS ONE, 6 11: e25966.1-e25966.7. doi:10.1371/journal.pone.0025966


Author Dean, Angela J.
Bellgrove, Mark
Hall, Teresa
Phan, Wei Ming Jonathan
Eyles, Darryl
Kvaskoff, David
McGrath, John J.
Title Effects of vitamin D supplementation on cognitive and emotional functioning in young adults: a randomised controlled trial
Journal name PLoS ONE   Check publisher's open access policy
ISSN 1932-6203
Publication date 2011-11-04
Sub-type Article (original research)
DOI 10.1371/journal.pone.0025966
Open Access Status DOI
Volume 6
Issue 11
Start page e25966.1
End page e25966.7
Total pages 7
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2012
Language eng
Formatted abstract
Background:  Epidemiological research links vitamin D status to various brain-related outcomes. However, few trials examine whether supplementation can improve such outcomes and none have examined effects on cognition. This study examined whether Vitamin D supplementation led to improvements in diverse measures of cognitive and emotional functioning, and hypothesised that supplementation would lead to improvements in these outcomes compared to placebo.

Methods/Principal Findings: Healthy young adults were recruited to a parallel-arm, double-blind trial conducted at The University of Queensland. Participants were randomly allocated to receive Vitamin D (one capsule daily, containing 5000 IU cholecalciferol) or identical placebo capsule for six weeks. All participants and outcome assessors were blinded to group assignment. Primary outcome measures assessed at baseline and 6 weeks were working memory, response inhibition and cognitive flexibility. Secondary outcomes were: hallucination-proneness, psychotic-like experiences, and ratings of depression, anxiety and anger. 128 participants were recruited, randomised and included in primary analyses (vitamin D n = 63; placebo n = 65). Despite significant increases in vitamin D status in the active group, no significant changes were observed in working memory (F = 1.09; p = 0.30), response inhibition (F = 0.82; p = 0.37), cognitive flexibility (F = 1.37; p = 0.24) or secondary outcomes. No serious adverse effects were reported.

Conclusions: Our findings indicate that vitamin D supplementation does not influence cognitive or emotional functioning in healthy young adults. Future controlled trials in targeted populations of interest are required to determine whether supplementation can improve functioning in these domains.

Australian and New Zealand Clinical Trials Registry; ACTRN12610000318088.
Keyword D deficiency
Older-adults
Performance
Population
Depression
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2012 Collection
School of Psychology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 43 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 55 times in Scopus Article | Citations
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Created: Mon, 12 Dec 2011, 16:06:04 EST by Debra McMurtrie on behalf of Queensland Brain Institute