Quantum dot penetration into viable human skin

Prow, Tarl W., Monteiro-Riviere, Nancy A., Inman, Alfred O., Grice, Jeffrey E., Chen, Xianfeng, Zhao, Xin, Sanchez, Washington H., Gierden, Audrey, Kendall, Mark A. F., Zvyagin, Andrei V., Erdmann, Detlev, Rivierer, Jim E. and Roberts, Michael S. (2012) Quantum dot penetration into viable human skin. Nanotoxicology, 6 2: 173-185. doi:10.3109/17435390.2011.569092

Author Prow, Tarl W.
Monteiro-Riviere, Nancy A.
Inman, Alfred O.
Grice, Jeffrey E.
Chen, Xianfeng
Zhao, Xin
Sanchez, Washington H.
Gierden, Audrey
Kendall, Mark A. F.
Zvyagin, Andrei V.
Erdmann, Detlev
Rivierer, Jim E.
Roberts, Michael S.
Title Quantum dot penetration into viable human skin
Journal name Nanotoxicology   Check publisher's open access policy
ISSN 1743-5390
Publication date 2012-03
Year available 2011
Sub-type Article (original research)
DOI 10.3109/17435390.2011.569092
Volume 6
Issue 2
Start page 173
End page 185
Total pages 13
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2012
Language eng
Abstract Systematic studies probing the effects of nanoparticle surface modification and formulation pH are important in nanotoxicology and nanomedicine. In this study, we use laser-scanning fluorescence confocal microscopy to evaluate nanoparticle penetration in viable excised human skin that was intact or tape-stripped. Quantum dot (QD) fluorescent nanoparticles with three surface modifications: Polyethylene glycol (PEG), PEG-amine (PEG-NH2) and PEG-carboxyl (PEG-COOH) were evaluated for human skin penetration from aqueous solutions at pH 7.0 and at pHs of solutions provided by the QD manufacturer: 8.3 (PEG, PEG-NH2) and 9.0 (PEG-COOH). There was some penetration into intact viable epidermis of skin for the PEG-QD at pH 8.3, but not at pH 7.0 nor for any other QD at the pHs used. Upon tape stripping 30 strips of stratum corneum, all QDs penetrated through the viable epidermis and into the upper dermis within 24 h.
Keyword Nanoparticles
Surface chemistry
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Epub ahead of print

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 40 times in Scopus Article | Citations
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Created: Thu, 08 Dec 2011, 09:49:51 EST by Nicole Lin on behalf of Medicine - Princess Alexandra Hospital