Indices of language outcome 11 years after intrathecal chemotherapy for acute lymphoblastic leukemia: A sibling case-control study

Lewis, Fiona M., Su, I-Fan and Murdoch, Bruce E. (2012) Indices of language outcome 11 years after intrathecal chemotherapy for acute lymphoblastic leukemia: A sibling case-control study. Pediatric Hematology and Oncology, 29 2: 176-190. doi:10.3109/08880018.2011.627417

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Author Lewis, Fiona M.
Su, I-Fan
Murdoch, Bruce E.
Title Indices of language outcome 11 years after intrathecal chemotherapy for acute lymphoblastic leukemia: A sibling case-control study
Journal name Pediatric Hematology and Oncology   Check publisher's open access policy
ISSN 0888-0018
1521-0669
Publication date 2012-03
Sub-type Article (original research)
DOI 10.3109/08880018.2011.627417
Volume 29
Issue 2
Start page 176
End page 190
Total pages 15
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2013
Language eng
Abstract Studies are emerging that suggest that major language indices do not differentiate children treated for acute lymphoblastic leukemia (ALL) with risk-adapted intrathecal chemotherapy (ITC) from control children matched on age, gender, and educational level. No study to date has controlled for cognitive environment, an important variable influencing language achievement and outcome. This case-control study applies the deconfounding principle by using a sibling as a control to investigate language outcomes in a male child 11 years after administration of ITC for ALL at the age of 2 years 3months. A comprehensive behavioral language test battery failed to differentiate the siblings on current language performance when descriptively compared, but neurophysiological assessment revealed that the ITC-treated child required more time and elicited a smaller N400 component compared to his sibling during picture-word matching. The findings suggest that in the absence of pretreatment performance indices, comparison with sibling achievement may supplement what is known on posttreatment language skill development drawn from comparative studies using children matched on age, sex, and educational level drawn from the community. The study’s findings offer pilot data of language outcomes following ITC beyond the early stage of survivorship. The benefits and limitations of using siblings in researchwhere the cognitive environment is known to make an important contribution to skill development are discussed.
Keyword All
Late effects
Neuro-oncology
Quality of life/psychosocial
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2013 Collection
School of Health and Rehabilitation Sciences Publications
 
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Created: Mon, 05 Dec 2011, 14:08:02 EST by Dr Fiona Lewis on behalf of School of Health & Rehabilitation Sciences